Encyclopedia of Radiation Oncology

2013 Edition
| Editors: Luther W. Brady, Theodore E. Yaeger

Complement-Dependent Cytotoxicity (CDC)

  • Tod W. Speer
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-85516-3_678

Definition

The immune process by which the antibody–antigen complex activates a cascade of proteolytic enzymes that ultimately results in the formation of a terminal lytic complex that is inserted into a cell membrane, resulting in lysis and cell death.

Cross-References

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Human OncologyUniversity of Wisconsin School of Medicine and Public Health, UW Hospital and ClinicsMadisonUSA