Sebaceous Gland Carcinoma: Overview
Rare, aggressive, malignant neoplasm arising from sebaceous glands of the skin adnexa.
In the United States, SGC is the fourth most common eyelid tumor after basal cell carcinoma, squamous cell carcinoma, and melanoma, and it represents approximately 5% (2–7%) of eyelid malignancies. In Asian countries like India and China, where basal cell carcinoma is less common, SGC represents about a third to a half of all malignant eyelid neoplasms.
SGC typically occurs in the sixth or seventh decade of life, with a wide age range from early childhood through the 90s. There is a predilection for women – more than one half up to three-fourths of cases occurs in women without any clear explanation for the preponderance (Niederhuber et al. 2013; Shields and Shields 2008).
The etiology is not entirely known. Though sebaceous gland carcinoma (SGC) is more common in elderly patients, it has been...
- Cummings TJ (2012) Ophthalmic pathology: a concise guide. Springer, New York, pp 61–67Google Scholar
- Eagle RC (2011) Eye pathology: an atlas and text, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 247–250Google Scholar
- Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE (2013) Abeloff’s clinical oncology, 5th edn. Saunders, PhiladelphiaGoogle Scholar
- Patterson JW (2013) Practical skin pathology: a diagnostic approach, 1st edn. Saunders, Philadelphia, pp 375–377Google Scholar
- Shields JA, Shields CL (2008) Eyelid, conjunctival, and orbital tumors: an atlas and textbook, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 51–64Google Scholar