Encyclopedia of Psychopharmacology

2010 Edition
| Editors: Ian P. Stolerman

Reversible Binding

  • Mark Slifstein
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-68706-1_799

Definition

The mode of interaction with receptors undergone by most neuroreceptor imaging tracers. Reversible means that the radiotracer will dissociate from the receptor-ligand complex with some regularity during the course of the imaging experiment, that is, that the ratio of the “on” rate of binding to the “off” rate of dissociation is not exceedingly large.

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Mark Slifstein
    • 1
  1. 1.Department of PsychiatryColumbia University and New York State Psychiatric InstituteNew YorkUSA