Encyclopedia of Psychopharmacology

2010 Edition
| Editors: Ian P. Stolerman

Social defeat

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-68706-1_1650


Social defeat is a procedure in which a smaller “intruder” rodent (rat or mouse) is introduced into the cage of a larger and aggressive “resident” rodent. The resident rat usually attacks the intruder rodent until it manifests a submissive posture. Additionally, the mere presence of the resident rodent (a threat condition) is sufficient to provoke physiological and behavioral stress responses in the intruder rodent that are similar to those obtained after the physical confrontation (Miczek et al., 2008).


Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Behavioral Neuroscience Branch, NIDA/IRPNational Institutes of HealthBaltimoreUSA
  2. 2.Department of Biomedical SciencesMarquette UniversityMilwaukeeUSA