Reference Work Entry

Encyclopedia of Psychopharmacology

pp 537-537

Fischer (F344)/Lewis (LEW) Rat Strains

  • Anthony L. RileyAffiliated withDepartment of Psychology, American University
  • , Steve KohutAffiliated withDepartment of Psychology, Psychopharmacology Laboratory, American University


The Fischer and Lewis rat strains are inbred rat strains independently developed as models of cancer susceptibility and tissue transplantation, respectively. Many differences between the F344 and LEW rats have been identified, leading to direct comparisons in studies of genetic contributions to disease-relevant differences in physiology and behavior, for example, drug susceptibility.


Inbred Strains

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