Synonym
EcR.
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Genomic ecdysteroid effects in insects and crustaceans are mediated via an intracellular ecdysteroid receptor (EcR). This receptor belongs to the superfamily of nuclear receptors and is related to all vertebrate steroid hormone receptors. In its functional form the EcR is usually a heterodimer of EcR and another transcription factor, belonging to the same superfamily, which is called ultraspiracle (USP) and which is a homologue to the vertebrate retinoid X receptor (RXR). EcR and USP are phosphoproteins and can occur in different splice variants. They possess a ligand (= Hormone) binding domain (LBD), a DNA binding domain (DBD), and a transactivation domain as well as interfaces for dimerization, interaction with heat shock proteins and comudulators, and for nuclear transport.
Highest ligand affinity has been shown for ponasterone A and muristerone A, followed by 20-hydroxyecdysone ( Ecdysteroids). Depending on the insect taxon high affinity for...
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© 2008 Springer-Verlag Berlin Heidelberg New York
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(2008). Ecdysteroid Receptor. In: Mehlhorn, H. (eds) Encyclopedia of Parasitology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48996-2_970
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DOI: https://doi.org/10.1007/978-3-540-48996-2_970
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-48994-8
Online ISBN: 978-3-540-48996-2
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