Serine-Threonine Kinase Receptor-Associated Protein
Synonyms
hMAWD: Human MAPK activator with WD repeats; Unrip: unr-interacting protein; STRAP
Definition
STRAP is a 39 kDa protein of WD-40 family involved in probable chaperoning function during the formation of multiprotein complexes shown to be active in the Transforming growth factor-β (TGF-β) receptor signaling network and U-rich small nuclear ribonucleoprotein (U snRNP) assembly. Oncogenic STRAP is up-regulated in human cancers and may be involved in tumor progression.
Characteristics
STRAP was first cloned from mouse embryonic cDNA library while searching for novel proteins that bind the cytoplasmic region of TGF-β type I receptor (TβRI) using yeast two-hybrid screening. Later it was found that STRAP could associate with both type I and type II (TβRII) serine-threonine kinase receptors. Southern blot analyses demonstrate that STRAP is evolutionarily conserved from yeast to mammals. The importance of this conservation was revealed when STRAP knockout mice were generated using...
References
- 1.Buess M, Terracciano L, Reuter J et al. (2004) STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer. Neoplasia 6(6):813–820PubMedGoogle Scholar
- 2.Datta P, Chytil A, Gorska A et al. (1998) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem 273(52):34671–34674PubMedGoogle Scholar
- 3.Datta P, Moses H (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol 20(9):3157–3167PubMedGoogle Scholar
- 4.Halder S, Anumanthan G, Maddula R et al. (2006) Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res 66(12):6156–6166PubMedGoogle Scholar
- 5.Seong H, Jung H, Choi H et al. (2005) Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. J Biol Chem 280(52):42897–42908PubMedGoogle Scholar