Encyclopedia of Cancer

2009 Edition
| Editors: Manfred Schwab

ROD-ZW10-Zwilch Complex

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-47648-1_5121

Definition

RZZ; Is composed by three proteins, Rough Deal (Rod), Zeste-white 10 (Zw10) and Zwilch. The RZZ complex is responsible for both Mad1 and Mad2 recruitment to unattached kinetochores and is involved in activation of the spindle assembly  checkpoint.

 Mitotic Arrest-Deficient Protein 1

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© Springer-Verlag Berlin Heidelberg New York 2008