Podoplanin
Synonyms
gp36; Human podoplanin; OTS-8, gp38, T1α2, PA2.26, RANDAM-2, Aggrus; Mouse podoplanin; E11 antigen, RTI40; Rat podoplanin
Definition
Human podoplanin is a type-1 transmembrane glycoprotein consisting of 162 amino acids, nine of which form the intracellular domain. The extracellular domain is extensively O-glycosylated. Depending on glycosylation, the molecular mass is between 36 and 45 kDa. Podoplanin is physiologically expressed in kidney podocytes, skeletal muscle, placenta, lung, heart, myofibroblasts of the breast and salivary glands, osteoblasts and mesothelial cells, and on the apical surface of alveolar type I cells. Occasionally, focal expression of podoplanin can be found in circumscribed areas of the basal layer of the human epidermis. Podoplanin is also expressed in lymphatic endothelium, but not in blood vessels. Pathological expression of podoplanin is observed in many human cancers, in particular squamous cell carcinomas.
Characteristics
In tumors, podoplanin is...
References
- 1.Hantusch B, Kalt R, Krieger S et al. (2007) Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells. BMC Mol Biol 8:20PubMedGoogle Scholar
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- 4.Wicki A, Christofori G (2007) The potential role of podoplanin in tumour invasion. Br J Cancer 96:1–5PubMedGoogle Scholar
- 5.Wicki A, Lehembre F, Wick N et al. (2006) Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 9:261–272PubMedGoogle Scholar