Refers to  stem cell transplant; synonym mini-transplant, transplant-lite, or reduced intensity transplant. Is a stem cell transplant from a donor ( allogeneic) that uses a less aggressive combination of chemotherapy and/or radiation to prepare the patient for the transplant. In the “conventional” allogeneic transplant the goals of the preparative chemotherapy/radiation are to kill as many cancer cells as possible and to suppress the immune system of the patient to allow the donor cells to grow. The non-myeloablative transplant aims just to suppress the patient's immune system sufficiently to allow engraftment of the donor cells.

 Chronic Lymphocytic Leukemia