Skip to main content

Arachidonic Acid Pathway

  • Reference work entry
  • 113 Accesses

Synonyms

Cyclooxygenase; COX; metabolism; Lipoxygenase; LOX; metabolism; eicosanoid signaling

Definition

The arachidonic acid pathway describes the biosynthesis of eicosanoids from arachidonic acid (AA) including its formation from omega-6 polyunsaturated fatty acids (PUFAs) and the synthesis of eicosanoids from eicosapentaenoic acid (EPA) including its formation from omega-3 PUFAs. Eicosanoids are short-lived biologically potent, autocrine or paracrine acting, lipid signaling molecules.

Characteristics

The AA pathway is involved in many physiological processes including inflammation and cancer. The pleiotropic effects of modulating this pathway are manifold and are depending on the levels of fatty acids from (dietary) substrates, which in turn modulate the level of eicosanoid precursors (AA and EPA) determining the amounts of eicosanoid lipid mediators actually produced. Initial and still ongoing research on the pharmacological inhibition of inflammatory reactions by nonsteroidal...

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-540-47648-1_380
  • Chapter length: 6 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   2,159.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-47648-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Arachidonic Acid Pathway. Figure 1
Arachidonic Acid Pathway. Figure 2

References

  1. Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A (2004) Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 79(6):935–945

    PubMed  CAS  Google Scholar 

  2. Furstenberger G, Krieg P, Muller-Decker K et al. (2006) What are cyclooxygenases and lipoxygenases doing in the driver’s seat of carcinogenesis? Int J Cancer 119(10):2247–2254

    PubMed  CAS  Google Scholar 

  3. Weylandt KH, Kang JX (2005) Rethinking lipid mediators. Lancet 366(9486):618–620

    PubMed  Google Scholar 

  4. Ulrich CM, Bigler J, Potter JD (2006) Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer 6(2):130–140

    PubMed  CAS  Google Scholar 

  5. Buchanan FG, Dubois RN (2006) Connecting COX-2 and Wnt in cancer. Cancer Cell 9(1):6–8

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg New York

About this entry

Cite this entry

Kranen, H.J.v., Siezen, C.L.E. (2008). Arachidonic Acid Pathway. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_380

Download citation