MCT-1 Oncogene
Synonyms
MCTS1
Definition
MCT-1 is an oncogene initially identified in a human T-cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. The MCT-1 protein MCT-1 contains a PUA domain, which is a recently described RNA binding domain. MCT-1 interacts with the cap-binding complex and modulates the translation profiles of a subset of mRNAs.
Characteristics
The MCT-1 oncogene is mapped to chromosome Xq22–24. MCT-1 was shown to interact with the density-regulated protein (DENR/DRP), a protein whose expression is increased in cultured cells grown at high density. DENR has a SUI1 domain which is involved in recognition of the initiation codon by the eIF2-GTP-Met-tRNAi ternary complex. Together MCT-1 and DENR form a functional unit which binds to the cap binding complex either directly or indirectly through interaction with eIF4E.
Regulation
Expression analysis of a variety of normal human tissues revealed low level ubiquitous expression...
References
- 1.Prosniak M, Dierov J, Okami K et al. (1998) A novel candidate oncogene, MCT-1, is involved in cell cycle progression. Cancer Res 58(19):4233–4237PubMedGoogle Scholar
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- 3.Sinnathamby L, Nandi S, Helen Hui BS et al. (2006) MCT-1protein interacts with the Cap complex and modulates mRNA translational profiles. Cancer Res 66(18):8994–9001Google Scholar
- 4.Nandi S, Reinert LS, Hachem A et al. (2006) Phosphorylation of MCT-1 by p42/44 MAPK is required for its stabilization in response to DNA damage. Oncogene [Epub ahead of print]Google Scholar
- 5.Fleischer TC, Weaver CM, McAfee KJ et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294–1307PubMedGoogle Scholar