Transforming Oncogenes
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-38918-7_6918
The growth of tumours can be regarded as the result of an accumulation of genetic changes in a wide variety of genes, the incorrect activation of oncogenes and the loss of function of tumour suppressor genes. Oncogenes are defined on the basis of their gain of function. The number of oncogenes isolated since about the end of the 1970s has grown to over 250.
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© Springer-Verlag Berlin Heidelberg New York 2008