Interferon Stimulated Gene 15
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-38918-7_5987
Synonyms
ISG15
Definition
ISG15 is one the genes most strongly induced by type I interferons. Transcription is also up regulated upon viral infection, oxidative stress and treatment with lipopolysaccharide (LPS). Like ubiquitin, ISG15 can be conjugated to a wide range of target proteins. As mice lacking ISG15 are more sensitive upon herpes‐ and influenza‐infections the ISG15 system apparently has a pivotal role in antiviral defense.
Copyright information
© Springer-Verlag Berlin Heidelberg New York 2008