Reference Work Entry

Encyclopedia of Molecular Pharmacology

pp 51-51


AIDS (acquired immunodeficiency syndrome) is the final stage of disease caused by infection with HIV. In this stage, the virus infection has severely affected the immune system, causing a depletion of CD4+ T‐helper cells. AIDS is characterized by the manifestation of typical diseases caused by opportunistic infections (Pneumocystis carinii pneumonia, CMV retinitis, candidiasis of the esophagus, cerebral toxoplasmosis), neurological manifestations, cachexia, or certain tumors (Kaposi sarcoma of the skin, B‐cell lymphoma).

Antiviral Drugs

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