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Glycoscience pp 1795-1857 | Cite as

Biologically Relevant Glycopeptides: Synthesis and Applications

  • Clay S. Bennett
  • Richard J. Payne
  • Kathryn M. Koeller
  • Chi-Huey WongEmail author

Abstract

Over the past two decades interest in glycopeptides and glycoproteins has intensified, due in part to the development of new and efficient methods for the synthesis of these compounds. This includes a number of chemical and enzymatic techniques for incorporating glycosylation onto the peptide backbone as well as the introduction of powerful peptide ligation methods for the construction of glycoproteins. This review discusses these methods with a special emphasis on biologically relevant glycopeptides and glycoproteins. This includes the development of a number of antigens which hold promise as potential vaccines for HIV, cancer, or a host of other clinically important diseases. In addition the development of new antibiotics aimed at overcoming the problem of resistance will be discussed. Finally, chemical and enzymatic methods for the construction of glycopeptide mimetics will be described.

Keywords

Solid-phase Ligation Chemoenzymatic Vaccine Antigen Conjugation Antibiotic Immune response Inflammatory response Conformation Mimetic 

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 2008

Authors and Affiliations

  • Clay S. Bennett
    • 1
  • Richard J. Payne
    • 2
  • Kathryn M. Koeller
    • 1
  • Chi-Huey Wong
    • 1
    Email author
  1. 1.Chemistry DepartmentThe Scripps Research InstituteLa JollaUSA
  2. 2.School of ChemistryThe University of SydneySydneyAustralia

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