Non-topographic organization contrasts with topographic/somatotopic organization and favors the notion that the region is involved in affect-motivation. Khanna and Sinclair (1992) reported that a noxious heat stimulus, whether applied to the hind paw or the tail, suppressed CA3 stimulation-elicited CA1 pyramidal cell excitation at a given site in the hippocampus.

 Nociceptive Processing in the Hippocampus and Entorhinal Cortex, Neurophysiology and Pharmacology