Synonyms
Spared Nerve Injury Model; SNI Model; Sural Spared Nerve Injury Model; sSNI Model
Definition
The rodent spared nerve injury model (SNI) consists of the selective injury of two of the three terminal branches of the sciatic nerve (the tibial and common peroneal nerve), leaving the third branch, the sural nerve, intact (Decosterd and Woolf 2000). Rapid and robust pain hypersensitivity to mechanical and thermal external stimuli is produced in the sural nerve skin territory, similar to stimulus-evoked pain observed in clinical neuropathic pain syndromes.
Characteristics
Description of the Model
Since the original description of anesthesia dolorosaby Wall (Wall et al. 1979), several models of transection/ligation-related injury to peripheral nerves have been described, allowing evaluation of the response to an applied external innocuous or nociceptive stimulus (stimulus-evoked pain) (Mosconi and Kruger 1996; Seltzer et al. 1990; Kim and Chung 1992; Bennett and Xie 1988; Vos et al....
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References
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Decosterd I, Woolf CJ (2000) Spared Nerve Injury: An Animal Model of Persistent Peripheral Neuropathic Pain. Pain 87:149–158
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Kim SH, Chung JM (1992) An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat. Pain 50:355–363
Mosconi T, Kruger L (1996) Fixed-Diameter Polyethylene Cuffs Applied to the Rat Sciatic Nerve Induce a Painful Neuropathy - Ultrastructural Morphometric Analysis Of Axonal Alterations. Pain 64:37–57
Seltzer Z, Dubner R, Shir Y (1990) A Novel Behavioral Model of Neuropathic Pain Disorders Produced in Rats by Partial Sciatic Nerve Injury. Pain 43:205–218
Vos BP, Strassman AM, Maciewicz RJ (1994) Behavioral Evidence of Trigeminal Neuropathic Pain Following Chronic Constriction Injury to the Rat's Infraorbital Nerve. J Neurosci 14:2708–2723
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© 2007 Springer-Verlag Berlin Heidelberg
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Decosterd, I. (2007). Neuropathic Pain Model, Spared Nerve Injury. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_2682
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DOI: https://doi.org/10.1007/978-3-540-29805-2_2682
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43957-8
Online ISBN: 978-3-540-29805-2
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