Reference Work Entry

Encyclopedia of Neuroscience

pp 554-554

Calcium Chelator


Calcium ions have a double positive charge. Calcium chelators are molecules that bind calcium and cover the ion in a way that it is no longer available for cellular metabolism. It was the invention of calcium chelators that allowed understanding the role of calcium in biological cells, because calcium concentrations in cells are so low that it is impossible to create artificial solutions with lower calcium concentrations unless calcium is removed using chelators. The event of calcium chelators, that can be titrated to create known calcium concentrations, made this ion accessible to direct experimental analysis.

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