Neuropeptides in Energy Balance
Synonyms
Polypeptide; Energy homeostasis; Energy state; Appetite regulation; Food intake; Hypothalamus
Definition
Energy balance refers to the homeostasis between positive and negative energy states in an organism and is controlled by the regulation of food intake and energy expenditure. In higher organisms, these processes are regulated by the brain, where the hypothalamus assumes an important role. The hypothalamic circuitry involved includes peptide chemical messengers. These neuropeptides can be orexigenic, stimulating increased energy intake and tending to decrease energy expenditure, or anorexigenic, reducing energy intake and promoting increased energy expenditure. Here, we discuss the main hypothalamic neuropeptides that modulate the central circuitry involved in energy homeostasis, and their integration of peripheral peptide and protein hormone signals of energy balance.
Characteristics
Neuropeptide Modulation of Hypothalamic Circuitry
Early experiments investigating the role...
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