Encyclopedia of Neuroscience

Editors: Marc D. Binder, Nobutaka Hirokawa, Uwe Windhorst

Cortico-Subcortical Re-Entrant Circuit

  • Henk J. Groenewegen
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29678-2_1299


Basal ganglia-thalamocortical circuit; Cortical-basal ganglia circuit; Basal ganglia-thalamocortical loop


Cortico-subcortical re-entrant circuits are composed of a series of connections that start in a particular part of the cerebral cortex and lead via subsequent steps in the basal ganglia and the thalamus back to the same part of the cortex. More in particular, cytoarchitectonically and functionally distinct cortical areas in the frontal lobe form the focal point of these circuits. Each frontal cortical area projects to a specific region of the striatum and that striatal region projects via the globus pallidus or substantia nigra to a particular thalamic nucleus or part thereof. This part of the thalamus, in turn, is in reciprocal connection with the original frontal cortical area, closing the circuit (Fig. 1).
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  1. 1.
    Nauta WJH, Mehler WR (1966) Projections of the lentiform nucleus in the monkey. Brain Res 1:3–42PubMedCrossRefGoogle Scholar
  2. 2.
    Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381PubMedCrossRefGoogle Scholar
  3. 3.
    Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Prog Brain Res 85:119–146PubMedCrossRefGoogle Scholar
  4. 4.
    Gerfen CR (1992) The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu Rev Neurosci 15:285–320PubMedCrossRefGoogle Scholar
  5. 5.
    Mink JW (1996) The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol 50:381–425PubMedCrossRefGoogle Scholar
  6. 6.
    Groenewegen HJ, Berendse HW (1994) The specificity of the non-specific midline and intralaminar thalamic nuclei. Trends Neurosci 17:52–57PubMedCrossRefGoogle Scholar
  7. 7.
    Zahm DS (2000) An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci Biobehav Rev 24:85–105PubMedCrossRefGoogle Scholar
  8. 8.
    Haber SN, Fudge JL, McFarland NR (2000) Striatonigral pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci 20:2369–2382PubMedGoogle Scholar
  9. 9.
    DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13:281–285PubMedCrossRefGoogle Scholar
  10. 10.
    Mega MS, Cummings JL (1994) Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 6:358–370PubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2009

Authors and Affiliations

  • Henk J. Groenewegen
    • 1
  1. 1.Institute for Clinical and Experimental Neurosciences, Department of Anatomy and NeurosciencesVU University medical centerAmsterdamThe Netherlands