Reference Work Entry

Encyclopedia of Neuroscience

pp 812-812



An important innate immune system composed of almost 30 proteins expressed by phagocytes, glial cells, neurons and most other cell types. C3 is the canonical complement protein with the capacity to bind to pathogens and promoting clearance by phagocytes expressing C3 receptors. Small fragments of C3 called C3a and C5a anaphylatoxins have stimulatory activities through signaling to G-protein-coupled seven transmembrane receptors.

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