Combinatorial Transcription Factor Codes and Neuron Specification
Transcription factor codes; Combinatorial action of transcription factors; Neuronal determination; Neuronal differentiation
Cellular definition. i) A combination of transcription factors that is required together to activate or repress a certain gene in a certain cell. ii) A combination of transcription factors that is required together to execute a neuron’s distinct differentiation program.
Developmental definition. i) The difference in the combination of transcription factors, between neurons, that accounts for their distinct gene expression profiles. ii) A spatial or temporal transition in transcription factor expression that confers a distinct program of neuronal differentiation or gene expression.
The nervous system contains many different types of neurons, whose differences ultimately reside in their...