Reference Work Entry

Encyclopedia of Molecular Mechanisms of Disease

pp 775-776

Hashimoto's Thyroiditis

  • Seda SancakAffiliated withMarmara University Medical SchoolIII. Medical Department, University of Leipzig
  • , Ralf PaschkeAffiliated withIII. Medical Department, University of Leipzig


Hashimoto's disease; Goitrous autoimmune thyroiditis [1]

Definition and Characteristics

Positive thyroid peroxidase antibodies (TPO Ab), elevated serum thyrotropin, lymphocytic infiltration of the thyroid gland and presence of a goiter on clinical examination [1].


The most common cause of acquired hypothyroidism [1,2], sevenfold more common in women [1] with increasing incidence after the age of 45 [3].


There is a genetic predisposition for Hashimoto's thyroiditis, as patients with human leukocyte antigen (HLA) class I and class II (HLA-DR3, HLA-DR4, HLA-DR5), polymorphisms in the region of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene on chromosome 2q33 or on chromosomes 6p, 13q32, 12q22 are more susceptible to the development of Hashimoto's thyroiditis [4].

Molecular and Systemic Pathophysiology

Hashimoto's thyroiditis is characterized by diffuse lymphocytic infiltration, ...

This is an excerpt from the content