Encyclopedia of Molecular Mechanisms of Disease

2009 Edition
| Editors: Florian Lang


  • Martin Wabitsch
  • Klaus-Michael Debatin
  • Pamela Fischer Posovzsky
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29676-8_1364


Acquired lipodystrophy; Localized lipodystrophy; Centrifugal lipodystrophy

Definition and Characteristics

The lipodystrophy syndromes are rare disorders characterized by the loss of adipose tissue [1]. The loss of fat tissue can have genetic, immune, or infectious/drug-associated causes. Metabolic complications, such as insulin resistance, diabetes mellitus, hypertriglyceridemia, and fatty liver, increase in severity with the extent of fat loss. Lipodystrophies can be divided into two subtypes: familial and acquired. Causative mutations have recently been identified in one form of familial lipodystrophy as well as in one form of acquired lipodystrophy. Several mouse models might help understanding the development of these syndromes.

Panniculitis describes a clinical symptom caused by an inflammation of subcutaneous adipose tissue followed by a loss of adipose tissue. Panniculitis may be a sign of some forms of acquired lipodystrophy. Panniculitis may occur as an autoimmune...

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  1. 1.
    Fischer-Posovszky P, Debatin KM, Wabitsch M (2002) Lipodystrophies. Klin Padiatr 214:99–103PubMedGoogle Scholar
  2. 2.
    Garg A (2004) Acquired and inherited lipodystrophies. N Engl J Med 350:1220–1234PubMedGoogle Scholar
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    Fischer-Posovszky P, Hebestreit H, Hofmann AK, Strauss G, Moller P, Debatin KM, Wabitsch M (2006) Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy. J Clin Endocrinol Metab 91:1129–1135PubMedGoogle Scholar
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    Fischer-Posovszky P, Tornqvist H, Debatin KM, Wabitsch M (2004) Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit. Endocrinology 145:1849–1859PubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2009

Authors and Affiliations

  • Martin Wabitsch
    • 1
  • Klaus-Michael Debatin
    • 1
  • Pamela Fischer Posovzsky
    • 1
  1. 1.Division of Pediatric Endocrinology and DiabetesUniversity of UlmUlmGermany