Associations of Cytokine Polymorphisms with Immunosenescence

  • Elissaveta Naumova
  • Milena Ivanova
Reference work entry


The aging is a process characterized by progressive loss of function of the body, leading to decreased ability to environmental changes and maintenance of the homeostasis. Current data showing that aging processes may be associated with alterations in the immune system suggest that some of the genetic determinants of senescence might be polymorphic genes that regulate immune responses. In this chapter we will review the data on the role of cytokine gene polymorphisms in human longevity.


Cytokines Cytokine Gene Polymorphisms Immunosenescence Longevity 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elissaveta Naumova
    • 1
  • Milena Ivanova
    • 1
  1. 1.Department of Clinical ImmunologyUniversity Hospital “Alexandrovska”, Medical UniversitySofiaBulgaria

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