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Cell Surface Engineering

  • Srinivas Abbina
  • Nima Khadem Mohtaram
  • Jayachandran N. KizhakkedathuEmail author
Reference work entry
Part of the Polymers and Polymeric Composites: A Reference Series book series (POPOC)

Abstract

Recent preclinical studies demonstrated the use of engineered cells as a potential way to treat many diseases and disorders. Tailoring the cell’s function and interactions using surface engineering methods is a very promising approach in developing novel cell-based therapeutics. For instance, cell surface modification has been used for the development of universal blood donor cells. In another example, it has been shown that surface modification of stem cells is a doable approach to regulate the fate of cells into specific phenotypes, which is necessary to regain function in specific environment such as different injury sites. Cell surface engineering using macromolecules/polymers could provide desired properties and functions to cells for applications in targeted delivery, biosensing, transfection, imaging techniques, and in the regulation of cell fate. This chapter will review the recent advancements in polymer-based cell surface engineering approaches for various applications. In terms of the cell types, we have chosen to focus, specifically, on red blood cells, lymphocytes, splenocytes, stem cells (multipotent and pluripotent), islet cells, endothelial cells, and hepatocytes as they offer the most promise in generating cell-based therapeutics. In terms of modification approaches, we mainly highlighted the literature associated with the use synthetic polymers via covalent conjugation and non-covalent bonding. We also discuss the future of such cell surface engineering methods for their potential clinical utility.

Keywords

Cell surface engineering Polymers Bioconjugation Red blood cells Stem cells Islet cells Endothelial cells 

Abbreviations

AL

Alginate

BAEC

Bovine aortic endothelial cells

BNHS

Biotin N-hydroxysuccinimidyl

CAM

Cell adhesion molecules

CH-PC

Chitosan-graft-phosphorylcholine

CNS

Central nervous system

CP

Choline phosphate

DMPE

1,2-Dimyristoyl-sn-glycerol-3-phosphatidylethanolamine

EC

Endothelial cells

ECM

Extracellular matrix

ESCs

Embryonic stem cells

FGF2

Fibroblast growth factor 2

GAGs

Glycosaminoglycans

HPGs

Hyperbranched polyglycerols

HS

Heparan sulfate

HSCs

Hematopoietic stem cells

HTPs

HaloTag proteins

ICAM-1

Intercellular cell adhesion molecule-1

IPSC

Induced pluripotent stem cells

LbL

Layer-by-layer

Mal-Phe-PEG

Maleimidophenyl-PEG

m-PEG

Methoxypoly(ethylene glycol)

MSC

Mesenchymal stem cell

neoPGs

Neoproteoglycans

NHS

N-hydroxysuccinimidyl

NSCs

Neural stem cells

PBS

Phosphate-buffered saline

PEG

Poly(ethylene glycol)

PEI

Poly(ethyleneimine)

PEM

Polyelectrolyte multilayer film

PLL

Poly-l-lysine

PLL-PEG

Poly-l-lysine-graft-polyethylene glycol

PMNs

Polymorphonuclear leukocytes

PPG

Palmitated protein G

PSCs

Pluripotent stem cells

PVA

Poly(vinyl alcohol)

RBCs

Red blood cells

SDF-1

Stromal-derived factor-1

SLeX

Sialyl-Lewisx

SS

Succinimidyl succinate

VCAM

Vascular endothelial adhesion molecule

Notes

Acknowledgments

The authors acknowledge the funding by the Canadian Institutes of Health Research (CIHR) and from the Natural Sciences and Engineering Research Council (NSERC) of Canada to JNK. JNK holds a Career Investigator Scholar award from the Michael Smith Foundation for Health Research.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Srinivas Abbina
    • 1
    • 2
  • Nima Khadem Mohtaram
    • 1
    • 2
  • Jayachandran N. Kizhakkedathu
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Pathology and Laboratory MedicineUniversity of British ColumbiaVancouverCanada
  2. 2.Center for Blood ResearchUniversity of British ColumbiaVancouverCanada
  3. 3.Department of ChemistryUniversity of British ColumbiaVancouverCanada

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