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Design of Biomedical Polymers

  • Matthew Parrott
  • Stuart Dunn
Living reference work entry
Part of the Polymers and Polymeric Composites: A Reference Series book series (POPOC)

Abstract

The utilization of polymers for biomedical applications (“biomedical polymers”) has led to significant advancements in medicine. Biomedical polymers have made a profound impact on human health and improved the quality of life for many patients. Current and evolving biomedical challenges posed by disease, environmental triggers, and physiological processes demand the development of biomedical polymers with specific properties and function. To address these challenges, the design of biomedical polymers has become of paramount importance. Designing polymers with specific structures opens the door to tailored properties and function. In this chapter, we cover the design of biomedical polymers for a variety of applications. We show that key polymer structures and properties are crucial to desired functionality for a given application. The biomedical applications we cover include (1) drug delivery, (2) imaging and tracking biomedical polymers in vivo, (3) scaffolds for tissue engineering, (4) medical devices, (5) surgery and wound repair, and (6) biosensors. By looking at the polymer structure-property-function relationships provided herein, we hope that this will enable improved designs of biomedical polymers to realize enhanced performance and efficacy in transforming human health.

Abbreviations

CD

Cyclodextrin

DETOSU-HD

3,9-bis (ethylidene 2,4,8,10-tetraoxaspiro [5,5] undecane) and 1,6-hexanediol

DPCs

Dynamic polyconjugates

EPR

Enhanced permeability and retention

GPa

Gigapascal

HA

Hyaluronic acid

hMSCs

Human mesenchymal stem cells

HPMA

N-(2-hydroxypropyl)methacrylamide

IC50

Half maximal inhibitory concentration

MDa

Megadaltons

MMP2

Matrix metalloproteinase 2

MPa

Megapascals

PAMAM

Poly(amidoamine)

PANI

Poly(aniline)

PAsp

Poly(aspartic acid)

PBAE

Poly(beta-amino ester)

PBAVE

Poly(butyl and amino vinyl ether)s

PBS

Phosphate buffered saline

PCL

Poly(caprolactone)

PCPH

Poly[1,6-bis(p-carboxyphenoxy)hexane]

PEG

Poly(ethylene glycol)

PEI

Poly(ethyleneimine)

PEO

Poly(ethylene oxide)

PGA

Poly(glycolic acid)

PGlu

Poly(glutamic acid)

PLA

Poly(lactic acid)

PLCL

Poly(lactide-co-caprolactone)

PLGA

Poly(lactic-co-glycolic acid)

PLL

Poly(l-lysine)

POx

Poly(2-oxazoline)s

PRINT

Particle Replication In Non-wetting Templates

PSA

Poly(sebacic anhydride)

siRNA

Small interfering RNA

UHMWPE

Ultrahigh molecular weight poly(ethylene)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Radiology and Biomedical Research Imaging CenterUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Lineberger Comprehensive Cancer CenterChapel HillUSA

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