Bioactive Molecules in Food pp 2297-2315 | Cite as
Bioactive Compounds and Health Benefits of Jamun (Syzygium cumini)
Abstract
Jamun (Syzygium cumini) which is indigenous to India has been used as medicine for century in Unani and Ayurveda. The presence of bioactive compounds such as alkaloids, tannins, phenols, lipids, flavonoids in its leaves, barks, fruits, stems, and roots contributes to rich source for nutrition and medicine. Due to the presence these compounds, they have pharmacological effects with antioxidant, antimicrobial, antidiabetic, central nervous system activity (CNS), chemo preventive, anti-inflammatory, antiallergic, hepatoprotective, etc. properties. Jamun is commonly known for its antidiabetic activity as it has been proved to be the most promising nutraceutical value. Bioactive compounds are result of evolution, which may be due to specific requirement of plant by mutualistic or antagonistic interaction with another organism. The structure, action, metabolism, and health benefits of bioactive compounds in Jamun have been discussed in this article.
Keywords
Anthocyanin Bioactive compounds Biosynthetic pathway Human anatomy Pharmacology Syzygium cumini BioavailabilityReferences
- 1.Pichersky E, Gang DR (2000) Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective. Trends Plant Sci 5:439–445. https://doi.org/10.1016/S1360-1385(00)01741-6CrossRefPubMedGoogle Scholar
- 2.Forbey JS, Harvey AL, Huffman MA et al (2009) Exploitation of secondary metabolites by animals: a response to homeostatic challenges. Integr Comp Biol 49:314–328. https://doi.org/10.1093/icb/icp046CrossRefPubMedGoogle Scholar
- 3.Mukhopadhyay K, Chaudhary B (2012) Syzygium cumini (L.) SKEELS: A POTENTIAL SOURCE OF NUTRACEUTICALS. Int J Pharm Bio Sci 2:2230–7605Google Scholar
- 4.Warrier P, Nambiar V, Ramankutty C (1996) Indian medical plants, vol 5. Orient Longman Ltd, Hyderabad, pp 225–228Google Scholar
- 5.Anulika NP, Ignatius EO, Raymond ES et al (2016) The chemistry of natural product : plant secondary metabolites the chemistry of natural product : plant secondary. Meta 4:0–8Google Scholar
- 6.Shyamala Gowri S, Vasantha K (2010) Phytochemical screening and antibacterial activity of Syzygium cumini (L.) (Myrtaceae) leaves extracts. Int J PharmTech Res 2:1569–1573Google Scholar
- 7.Reddy J, Jose B (2013) Evaluation of antibacterial and DPPH radical scavenging activities of the leaf extracts of Cassia fistula Linn from South India. Open Access Sci Reports 2:2–5Google Scholar
- 8.Mohamed AA, Ali SI, El-Baz FK (2013) Antioxidant and antibacterial activities of crude extracts and essential oils of Syzygium cumini leaves. PLoS One. https://doi.org/10.1371/journal.pone.0060269CrossRefGoogle Scholar
- 9.Mahmood C, Daulatabad JD, Mirajkar AM et al (1988) Epoxy and cyclopropenoid fatty acids in Syzygium cuminii seed oil. J Sci Food Agric 43:91–94CrossRefGoogle Scholar
- 10.Swami SB, Thakor NSJ, Patil MM, Haldankar PM (2012) Jamun (Syzygium cumini L.): a review of its food and medicinal uses. Food Nutr Sci 3:1100–1117. https://doi.org/10.4236/fns.2012.38146CrossRefGoogle Scholar
- 11.Sadawarte P, Pujari K, Sonawane S (2016) Potential food applications and health benefits of Jambhul (Syzygium cuminii L.) Indian J. https://doi.org/10.21048/ijnd.2016.53.3.5340CrossRefGoogle Scholar
- 12.Sonawane S, Arya SS (2013) Antioxidant activity of jambhul, wood apple, ambadi and ambat chukka: an indigenous lesser known fruits and vegetables of India. Adv J Food Sci Technol 5:270–275CrossRefGoogle Scholar
- 13.Vasi S, Austin A (2009) Antioxidant potential of Eugenia jambolana Lam. Seeds. J Biol Sci 9:894–898. https://doi.org/10.3923/jbs.2009.894.898CrossRefGoogle Scholar
- 14.Paduch R, Kandefer-Szerszeń M, Trytek M, Fiedurek J (2007) Terpenes: substances useful in human healthcare. Arch Immunol Ther Exp 55:315–327. https://doi.org/10.1007/s00005-007-0039-1CrossRefGoogle Scholar
- 15.Cho KS, Lim YR, Lee K et al (2017) Terpenes from forests and human health. Toxicol Res 33:97–106. https://doi.org/10.5487/TR.2017.33.2.097CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Jäger W, Höferl M (2016) Metabolism of terpenoids in animal models and humans. In: Hüsnü Can Baser K, Buchbauer G (eds) Handbook of essential oil scince, technology and applications, 2nd edn. CRC Press/Taylor & Francis Group, Boca Raton, pp 253–280. https://doi.org/10.1201/b19393-10CrossRefGoogle Scholar
- 17.Clifford MN, Brown JE (2006) Dietary flavonoids and health. In: Anderson OM, Markham KR (eds) Flavonoids: chemistry, biochemistry and applications. CRC Press/Taylor & Francis Group, Boca Raton, pp 319–370Google Scholar
- 18.Shashank K, Abhay K (2013) Review article chemistry and biological activities of flavonoids: an overview. Sci World J 4:32–48. https://doi.org/10.1155/2013/162750Google Scholar
- 19.Reginold Jebitta S, Jeyanth Allwin S (2016) Antioxidant activity, total phenol, flavonoid, and anthocyanin contents of Jamun (Syzygium cumini) pulp powder. Asian J Pharm Clin Res 9:361–363Google Scholar
- 20.Aqil F, Jeyabalan J, Gupta A, Sharma RJ, Sidana J, Singh IP, Gupta RC (2010). Chemopreventive potential of ‘jamun’ (Indian blackberry) against estrogen-mediated mammary carcinogenesis. In: Proceedings of the 101st annual meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70 (8 Suppl): Abstract nr 5688Google Scholar
- 21.Kay CD (2006) Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans. Nutr Res Rev 19:137. https://doi.org/10.1079/NRR2005116CrossRefPubMedGoogle Scholar
- 22.Singh RK, Hosamani M, Balamurugan V et al (2006) An outbreak of buffalopox in buffalo (Bubalus bubalis) dairy herds in Aurangabad, India. Rev Sci Tech 25:981–987CrossRefGoogle Scholar
- 23.Rein MJ, Renouf M, Cruz-Hernandez C et al (2013) Bioavailability of bioactive food compounds: a challenging journey to bioefficacy. Br J Clin Pharmacol 75:588–602. https://doi.org/10.1111/j.1365-2125.2012.04425.xCrossRefPubMedPubMedCentralGoogle Scholar
- 24.Chagas VT, França LM, Malik S, Paes AM de A (2015) Syzygium cumini (L.) skeels: a prominent source of bioactive molecules against cardiometabolic diseases. Front Pharmacol 6:1–8. https://doi.org/10.3389/fphar.2015.00259CrossRefGoogle Scholar
- 25.Marín L, Miguélez EM, Villar CJ, Lombó F (2015) Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int. https://doi.org/10.1155/2015/905215CrossRefGoogle Scholar
- 26.van Duynhoven J, Vaughan EE, Jacobs DM et al (2011) Metabolic fate of polyphenols in the human superorganism. Proc Natl Acad Sci 108:4531–4538. https://doi.org/10.1073/pnas.1000098107CrossRefPubMedGoogle Scholar
- 27.Patel PR, Rao TVR (2012) Antibacterial activity of underutilized fruits of Jamun (Syzigium cumini). Intl J Curr Pharmaceut 4:36–39Google Scholar
- 28.Diamante L, Li S, Xu Q, Busch J (2013) Effects of apple juice concentrate, blackcurrant concentrate and pectin levels on selected qualities of apple-blackcurrant fruit leather. Foods 2:430–443. https://doi.org/10.3390/foods2030430CrossRefPubMedPubMedCentralGoogle Scholar
- 29.Rathi SS, Grover JK, Vikrant V, Biswas NR (2002) Prevention of experimental diabetic cataract by Indian Ayurvedic plant Extractst. Phyther Res 16:774–777. https://doi.org/10.1002/ptr.1064CrossRefGoogle Scholar
- 30.Kumar A, Ilavarasan R, Jayach T et al (2013) Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. J Med Plant Res 2:246–249Google Scholar
- 31.Deb L, Bhattacharjee C, Shetty SR, Dutta A (2013) Evaluation of anti-diabetic potential of the Syzygium cuminii (Linn) Skeels by reverse pharmacological approaches. Bull. Pharm Res 3:135–145Google Scholar
- 32.Leiva Díaz E, Giannuzzi L, Giner SA (2009) Apple pectic gel produced by dehydration. Food Bioprocess Technol 2:194–207. https://doi.org/10.1007/s11947-007-0035-9CrossRefGoogle Scholar
- 33.Atale N, Chakraborty M, Mohanty S et al (2013) Cardioprotective role of Syzygium cumini against glucose-induced oxidative stress in H9C2 cardiac myocytes. Cardiovasc Toxicol 13:278–289. https://doi.org/10.1007/s12012-013-9207-1CrossRefPubMedGoogle Scholar
- 34.Nandagopal PD, Subramonian SJ, Ganthi AS, Sankar S (2011) WOUND HEALING ACTIVITIES OF EUGENIA JAMBOLANA LAM . BARK EXTRACTS IN ALBINO RATS. Abstract: Wound healing is physiological process , which takes place by body’s natural regenerative capacity. Due to various reasons there may be delay in healing and thi. pp 112–116Google Scholar
- 35.Kumar A, Ilavarasan R, Jayachandran T et al (2008) Anti-inflammatory activity of Syzygium cumini seed. Afr J Biotechnol 7:941–943. https://doi.org/10.1016/S0367-326X(00)00325-7CrossRefGoogle Scholar
- 36.Saha S, Subrahmanyam EVS, Kodangala C et al (2013) Evaluation of antinociceptive and anti-inflammatory activities of extract and fractions of Eugenia jambolana root bark and isolation of phytoconstituents. Brazilian J Pharmacogn 23:651–661. https://doi.org/10.1590/S0102-695X2013005000055CrossRefGoogle Scholar
- 37.Pavan KK, Dharani PP, Narayana RA et al (2010) Anti-inflammatory activity of Eugenia jambolana in albino rats. Int J Pharm Bio Sci 1:8–11Google Scholar
- 38.Donepudi AC, Aleksunes LM, Driscoll MV et al (2012) The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis. Liver Int 32:560–573. https://doi.org/10.1111/j.1478-3231.2011.02724.xCrossRefPubMedGoogle Scholar
- 39.Babiuk S, Bowden TR, Boyle DB et al (2008) Capripoxviruses: an emerging worldwide threat to sheep, goats and cattle. Transbound Emerg Dis 55:263–272. https://doi.org/10.1111/j.1865-1682.2008.01043.xCrossRefPubMedGoogle Scholar
- 40.Bhanuprakash V, Hosamani M, Balamurugan V, Singh RK, Swarup D (2007) In vitro antiviral activity of Eugenia Jambolana plant extract on buffalopox virus: conventional and QPCR methods. Int J Trop Med 2:3–9Google Scholar
- 41.Bhanuprakash V, Hosamani M, Balamurugan V et al (2008) In vitro antiviral activity of plant extracts on goatpox virus replication. Indian J Exp Biol 46:120–127PubMedGoogle Scholar
- 42.Rock KL, Kono H (2008) The inflammatory response to cell death. Annu Rev Pathol Dis 3:67–97. https://doi.org/10.1146/annurev.pathCrossRefGoogle Scholar
- 43.Meigs JB (2010) Epidemiology of type 2 diabetes and cardiovascular disease: translation from population to prevention – the Kelly west award lecture 2009. Diabetes Care 33:1865–1871. https://doi.org/10.2337/dc10-0641CrossRefPubMedPubMedCentralGoogle Scholar
- 44.Sood R, Swarup D, Bhatia S et al (2012) Antiviral activity of crude extracts of Eugenia jambolana Lam. Against highly pathogenic avian influenza (H5N1) virus. Indian J Exp Biol 50:179–186PubMedGoogle Scholar
- 45.Quideau S (2006) Flavonoids. Chemistry, biochemistry and applications. Edited by Øyvind M. Andersen and Kenneth R. Markham. Angew Chem Int Ed. https://doi.org/10.1002/anie.200685399CrossRefGoogle Scholar
- 46.Kumar A (2007) Central nervous system activity of Syzygium cumini seed. Pakistan J6:698–700Google Scholar
- 47.Das S, Sarma G (2009) Study of the hepatoprotective activity of the ethanolic extract of the pulp of Eugenia Jambolona (Jamun) in albino rats. J Clin Diagn Res 3:1466–1474Google Scholar