Are Myristica fragrans L. (Myristicaceae) and Its Phytochemicals Useful for Human Health?

  • Monica Rosa LoizzoEmail author
  • Vincenzo Sicari
  • Jianbo Xiao
  • Rosa Tundis
Reference work entry
Part of the Reference Series in Phytochemistry book series (RSP)


From Myristica fragrans L. (Myristicaceae) two spices, nutmeg and mace, were obtained. This plant is traditionally used in China, India, and African countries for the treatment of several diseases, such as decreased appetite, diarrhea, muscle spasm, rheumatism, etc. Recently, M. fragrans has been investigated for antioxidant, anticonvulsant, analgesic, anti-inflammatory, antidiabetic, hypolipidemic and hypocholesterolemic, antibacterial, and antifungal potential.

A perusal analysis of literature evidenced that M. fragrans deserves more attention by scientific community to explore its full range of bioactivity in the welfare of the society especially in emergent Countries.


Myristica fragrans Chemical profile Bioactivity Toxicity 

List of Abbreviations






AMP-activated protein kinase




Diabetes mellitus


γ-Aminobutyric acid




Lactate dehydrogenase


Monocyte chemotactic protein


Macrophage inflammatory protein


Nitric oxide


Peripheral anionic site


Tetrahydrofuran mixture


Conflicts of Interest

The authors declare no conflicts of interest.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Monica Rosa Loizzo
    • 1
    Email author
  • Vincenzo Sicari
    • 2
  • Jianbo Xiao
    • 3
    • 4
  • Rosa Tundis
    • 1
  1. 1.Department of Pharmacy, Health and Nutritional SciencesUniversity of CalabriaRende, CosenzaItaly
  2. 2.Department of Agricultural ScienceMediterranean University of Reggio CalabriaReggio, CalabriaItaly
  3. 3.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese MedicineMacau UniversityTaipaMacau
  4. 4.Institut für Pharmazie und LebensmittelchemieUniversität WürzburgWürzburgGermany

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