Encyclopedia of Big Data Technologies

2019 Edition
| Editors: Sherif Sakr, Albert Y. Zomaya

Genomic Data Compression

  • Kaiyuan Zhu
  • Ibrahim Numanagić
  • S. Cenk SahinalpEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-77525-8_55


Genomic sequence data obtained through high-throughput sequencing (HTS) technologies are commonly stored either as raw sequencing reads in FASTQ format or as reads mapped to a reference genome in SAM format. Both of these formats have large memory footprints. Worldwide increase of HTS data has prompted the development of specialized compression methods that aim to significantly reduce HTS data size. Below is a comparative overview of available lossless genomic data compression approaches, including their advantages and pitfalls.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Kaiyuan Zhu
    • 1
  • Ibrahim Numanagić
    • 2
  • S. Cenk Sahinalp
    • 1
    Email author
  1. 1.Department of Computer ScienceIndiana University BloomingtonBloomingtonUSA
  2. 2.Computer Science and Artificial Intelligence LabMassachusetts Institute of TechnologyCambridgeUSA