Collagen-Based Hydrogels and Their Applications for Tissue Engineering and Regenerative Medicine

  • Sorina Dinescu
  • Madalina Albu Kaya
  • Leona Chitoiu
  • Simona Ignat
  • Durmus Alpaslan Kaya
  • Marieta CostacheEmail author
Living reference work entry
Part of the Polymers and Polymeric Composites: A Reference Series book series (POPOC)


A promising solution for soft tissue regeneration is tissue engineering, a multidisciplinary field of research which involves the use of biomaterials, growth factors, and stem cells in order to repair, replace, or regenerate tissues and organs damaged by injury or disease. The success of tissue engineering (TE) depends on the composition and microstructure of the used scaffolds. Ideally, scaffolds have to be similar to natural tissues. Collagen is the major component of the extracellular matrix of most soft tissues. The interactions between collagen and cells are vital in the wound healing process and in adult tissue remodeling, collagen being able to support differentiation and maintenance of cellular phenotype. As a natural molecule, collagen possesses the major advantage of being biodegradable, biocompatible, easily available, and highly versatile and presents low antigenicity. This chapter aims to present an overview on the structure, properties, and biomedical applications of collagen hydrogels. Moreover, it introduces the reader to the latest research in the field of tissue engineering related to collagen. It also displays the results we obtained as a joint bioengineering group on collagen hydrogels designed for soft (ATE) or cartilage tissue engineering (CTE) applications: type I collagen hydrogels improved with either silk sericin (CollSS) or with pro-chondrogenic factors – hyaluronic acid and chondroitin sulfate (CollSSHACS). Results indicated in both cases the positive influence of sericin on the interaction between cells and the surface of the hydrogels. In the absence of HA and CS, specific chondrogenic inducers, CollSS hydrogel is adapted for soft tissue reconstruction, whether the addition of HA and CS transforms CollSSHACS into a suitable hydrogel formula for semihard tissue repair via modern strategies in tissue engineering and regenerative medicine.


Collagen hydrogels Biomaterial Regenerative medicine Tissue engineering Sericin Hyaluronic acid Chondroitin sulfate 



The authors would like to acknowledge the funding sources that supported this work: grant 65PCCDI/2018 (REGMED), Project 3- dedicated to regeneration of soft tissues and to national project Bridge Grant PNIII-P2-2.1-BG-2016660 0458 (123BG/2016), as well as the National Executive Agency for Research Funding.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sorina Dinescu
    • 1
  • Madalina Albu Kaya
    • 2
  • Leona Chitoiu
    • 1
  • Simona Ignat
    • 1
  • Durmus Alpaslan Kaya
    • 3
  • Marieta Costache
    • 1
    Email author
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of BucharestBucharestRomania
  2. 2.Collagen DepartmentINCDTP – Leather and Footwear Research InstituteBucharestRomania
  3. 3.Department of Medicinal and Aromatic PlantsMustafa-Kemal UniversityHatayTurkey

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