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Polylactic Acid Based Hydrogels and Its Renewable Characters: Tissue Engineering Applications

  • Neha Mulchandani
  • Arvind Gupta
  • Vimal Katiyar
Living reference work entry
Part of the Polymers and Polymeric Composites: A Reference Series book series (POPOC)

Abstract

Derived from renewable sources, polylactic acid (PLA) is a thermoplastic aliphatic polyester, which is biodegradable and bioactive and being explored for various applications. PLA being hydrophobic in nature, often needs to be used in combination with a hydrophilic moiety in order to form hydrogels. PLA based hydrogels have found significant attention in biomedical applications. Hydrogels resemble the structure of many tissues and can be delivered to the patient using minimally invasive surgery along with their ease of processability which makes them potential scaffold materials. PLA is often considered a suitable candidate for scaffolds due to its biocompatible and bioresorbable nature. The current chapter highlights the importance of PLA based hydrogels in biomedical applications with significant focus on scaffolds for the treatment of damaged tissues. The essential criteria for selection of suitable materials to be used in combination with PLA for tissue engineering applications is presented, which would mimic the host tissue structure and allow the natural regeneration of tissue. Several case studies involving the use of PLA based hydrogels in tissue regeneration with their significant outcomes have been discussed. Furthermore, the investigations on cytotoxicity, cell adhesion, and proliferation are outlined for identifying the scope of these materials in tissue engineering applications.

Keywords

PLA Hydrogels Tissue engineering Biomedical 

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemical EngineeringIndian Institute of Technology GuwahatiGuwahatiIndia

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