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Health Impact of Airborne Fungi

  • Amal Saad-HusseinEmail author
  • Khadiga S. Ibrahim
Living reference work entry

Abstract

Fungi are ubiquitous microorganisms present in outdoor and indoor environments. There are relationships between environmental fungal exposures and human health effects. Exposure to indoor air pollutants might be more hazardous for inhabitants than exposure to outdoor air pollutants. Known health effects from fungal exposure include infection, illness from inhalation or ingestion of mycotoxins, and various hypersensitivity disorders. Exposure to high concentrations of indoor fungal spores can cause many health problems, such as bronchial asthma, in addition the health hazards of exposure to high concentrations of mycotoxins for long durations.

Mycotoxins are toxins naturally produced as secondary metabolites by some fungi, such as aflatoxins, ochratoxins, zearalenone, trichothecenes, and fumonisins. Aflatoxins appear particularly dangerous and capable of causing disease and death in both humans and animals because of their carcinogenic properties. Reducing moisture, killing fungi, and removing contaminated materials can decrease this risk of morbidity.

Keywords

Fungi Mycotoxins Health problem 

References

  1. Antonissen G, Martel A, Pasmans F et al (2014) The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases. Toxins (Basel) 6(2):430–452CrossRefGoogle Scholar
  2. Barnes C, Schreiber K, Pacheco F et al (2000) Comparison of outdoor allergenic particles and allergen levels. Ann Allergy Asthma Immunol 84:47–54PubMedCrossRefGoogle Scholar
  3. Bayman P, Baker JL (2006) Ochratoxins: a global perspective. Mycopathologia 162(3):215–223PubMedCrossRefGoogle Scholar
  4. Bennett JW, Klich M (2003) Mycotoxins. Clin Microbiol Rev 16(3):497–516PubMedPubMedCentralCrossRefGoogle Scholar
  5. Bensch K, Braun U, Groenewald JZ, Crous PW (2012) The genus Cladosporium. Stud Mycol 72:1–401PubMedPubMedCentralCrossRefGoogle Scholar
  6. Bondy GS, Pestka JJ (2000) Immunomodulation by fungal toxins. J Toxicol Environ Health B Crit Rev 3:109–143PubMedCrossRefGoogle Scholar
  7. Bui-Klimke TR, Wu F (2015) Ochratoxin A and human health risk: a review of the evidence. Crit Rev Food Sci Nutr 55(13):1860–1869PubMedPubMedCentralCrossRefGoogle Scholar
  8. Chen Q, Hildemann LM (2009) The effects of human activities on exposure to particulate matter and bioaerosols in residential homes. Environ Sci Technol 43(13):4641–4646PubMedCrossRefGoogle Scholar
  9. Cheng Z, Root M, Pan W et al (1997) Use of an improved method for analysis of urinary aflatoxin M1 in a survey of mainland China and Taiwan. Cancer Epidemiol Biomark Prev 6(7):523–529Google Scholar
  10. Chou H, Tam MF, Chiang CH et al (2011) Transaldolases are novel and immunoglobulin E cross-reacting fungal allergens. Clin Exp Allergy 41:739–749PubMedCrossRefGoogle Scholar
  11. Čulig B, Bevardi M, Bošnir J et al (2017) Presence of citrinin in grains and its possible health effects. Afr J Tradit Complement Altern Med 14(3):22–30PubMedPubMedCentralCrossRefGoogle Scholar
  12. da Silva EO, Bracarense APFL, Oswald IP (2018) Mycotoxins and oxidative stress: where are we. World Mycotoxin J 11(1):113–133CrossRefGoogle Scholar
  13. Dedesko S, Stephens B, Gilbert JA, Siegel JA (2015) Methods to assess human occupancy and occupant activity in hospital patient rooms. Build Environ 90:136–145CrossRefGoogle Scholar
  14. Després VR, Huffman JA, Burrows SM et al (2012) Primary biological aerosol particles in the atmosphere: a review. Tellus B 64.  https://doi.org/10.3402/tellusb.v64i0.15598CrossRefGoogle Scholar
  15. Devreese M, de Backer P, Croubels S (2013) Overview of the most important mycotoxins for the pig and poultry husbandry. Vlaams Diergeneeskundig Tijdschrift 82:171–180Google Scholar
  16. Duarte SC, Pena A, Lino CM (2011) Human ochratoxin A biomarkers – from exposure to effect. Crit Rev Toxicol 41:187–212PubMedCrossRefGoogle Scholar
  17. Eduard W, Heederik D, Duchaine C, Green BJ (2012) Bioaerosol exposure assessment in the workplace: the past, present and recent advances. J Environ Monit 14(2):334–339PubMedPubMedCentralCrossRefGoogle Scholar
  18. Etzel RA, Montana E, Sorenson WG et al (1998) Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med 152:757–762PubMedCrossRefGoogle Scholar
  19. Farombi EO, Nwaokeafor IA (2005) Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats. Clin Exp Pharmacol Physiol 32:667–674PubMedCrossRefGoogle Scholar
  20. Föllmann W, Behm C, Degen GH (2014) Toxicity of the mycotoxin citrinin and its metabolite dihydrocitrinone and of mixtures of citrinin and ochartoxin A in vitro. Arch Toxicol 88:1097–1107PubMedCrossRefGoogle Scholar
  21. Georgakopoulos DG, Despres V, Frohlich-Nowoisky J et al (2009) Microbiology and atmospheric processes: biological, physical and chemical characterization of aerosol particles. Biogeosciences 6:721–737CrossRefGoogle Scholar
  22. Groopman JD, Dematos P, Egner PA et al (1992a) Molecular dosimetry of urinary aflatoxin-n7-guanine and serum aflatoxin albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis 13(1):101–106PubMedCrossRefGoogle Scholar
  23. Groopman JD, Jiaqi Z, Donahue PR et al (1992b) Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi autonomous region, People’s Republic of China. Cancer Res 52(1):45–52PubMedGoogle Scholar
  24. Hagelberg S, Hult K, Fuchs R (1989) Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J Appl Toxicol 9:91–96PubMedCrossRefGoogle Scholar
  25. Haighton LA, Lynch BS, Magnuson BA, Nestmann ER (2012) A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model. Crit Rev Toxicol 42:147–168PubMedPubMedCentralCrossRefGoogle Scholar
  26. Hall AJ, Wild CP (1994) Epidemiology of aflatoxin related disease. In: Eaton DL, Groopman JD (eds) The toxicology of aflatoxins: human health, veterinary, and agricultural significance. Academic, San Diego, pp 223–258Google Scholar
  27. Hamid AS, Tesfamariam IG, Zhang Y, Zhang ZG (2013) Aflatoxin B1-induced hepatocellular carcinoma in developing countries: geographical distribution, mechanism of action and prevention. Oncol Lett 5(4):1087–1092PubMedPubMedCentralCrossRefGoogle Scholar
  28. Harrison J, Pickering CA, Faragher EB et al (1992) An investigation of the relationship between microbial and particulate indoor air pollution and the sick building syndrome. Respir Med 86:225–235PubMedCrossRefGoogle Scholar
  29. Hussein HS, Brasel JM (2001) Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167:101–134PubMedCrossRefGoogle Scholar
  30. Johanning E, Biagini R, Hull D et al (1996) Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. Int Arch Occup Environ Health 68:207–218PubMedGoogle Scholar
  31. Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism – from biochemistry to genomics. Nat Rev Microbiol 3(12):937–947PubMedCrossRefGoogle Scholar
  32. Kosalec I, Cvek J, Tomić S (2009) Contaminants of medicinal herbs and herbal products. Arh Hig Rada Toksikol 60:485–501PubMedCrossRefGoogle Scholar
  33. Kuhn DM, Ghannoum MA (2003) Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective. Clin Microbiol Rev 16:144–172PubMedPubMedCentralCrossRefGoogle Scholar
  34. Kuiper-Goodman T, Scott PM (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2:179PubMedPubMedCentralGoogle Scholar
  35. Lee BU (2011) Life comes from the air: a short review on bioaerosol control. Aerosol Air Qual Res 11:921–927CrossRefGoogle Scholar
  36. Levetin E (2004) Methods for aeroallergen sampling. Curr Allergy Asthma Rep 4:376–383PubMedCrossRefPubMedCentralGoogle Scholar
  37. Lighthart B (2000) Mini-review of the concentration variations found in the alfresco atmospheric bacterial populations. Aerobiologia 16(1):7–16CrossRefGoogle Scholar
  38. Liu Y, Wu F (2010) Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 118(6):818–824PubMedPubMedCentralCrossRefGoogle Scholar
  39. Mahfoud R, Maresca M, Garmy N, Fantini J (2002) The mycotoxin patulin alters the barrier function of the intestinal epithelium: mechanism of action of the toxin and protective effects of glutathione. Toxicol Appl Pharmacol 181(3):209–218PubMedCrossRefPubMedCentralGoogle Scholar
  40. Mandal J, Brandl H (2011) Bioaerosols in indoor environment-a review with special reference to residential and occupation allocations. Open Environ Biol Monit J 4:83–96CrossRefGoogle Scholar
  41. Marquardt RR, Frohlich AA (1992) A review of recent advances in understanding ochratoxicosis. J Anim Sci 70:3968–3988PubMedCrossRefGoogle Scholar
  42. Martins ML, Martins HM, Bernardo F (2001) Aflatoxins in spices marketed in Portugal. Food Addit Contam 18(4):315–319PubMedCrossRefGoogle Scholar
  43. Mateo R, Medina A, Mateo EM et al (2007) An overview of ochratoxin A in beer and wine. Int J Food Microbiol 119(1–2):79–83PubMedCrossRefGoogle Scholar
  44. Méheust D, Le Cann P, Reboux G et al (2014) Indoor fungal contamination: health risks and measurement methods in hospitals, homes and workplaces. Crit Rev Microbiol 40(3):248–260PubMedCrossRefGoogle Scholar
  45. Mendell MJ, Mirer AG, Cheung K et al (2011) Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environ Health Perspect 119:748–756PubMedPubMedCentralCrossRefGoogle Scholar
  46. Moss MO (2008) Fungi, quality and safety issues in fresh fruits and vegetables. J Appl Microbiol 104(5):1239–1243PubMedCrossRefGoogle Scholar
  47. National Toxicology Program (NTP) (2011) Report on carcinogens, 12th edn. U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, Research Triangle Park, 499 pp. http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12.pdfGoogle Scholar
  48. Nielsen FK (2003) Mycotoxin production by indoor molds. Fungal Genet Biol 39(2):103–117CrossRefGoogle Scholar
  49. Pal S, Singh N, Ansari KM (2017) Toxicological effects of patulin mycotoxin on the mammalian system: an overview. Toxicol Res (Camb) 6(6):764–771CrossRefGoogle Scholar
  50. Pashley CH, Fairs A, Free RC, Wardlaw AJ (2012) DNA analysis of outdoor air reveals a high degree of fungal diversity, temporal variability, and genera not seen by spore morphology. Fungal Biol 116:214–224PubMedCrossRefGoogle Scholar
  51. Pastuszka JS, Tha-Paw UK, Lis DO et al (2000) Bacterial and fungal aerosol in indoor environment in Upper Silesia. Poland. Atmos Environ 34:3833–3842CrossRefGoogle Scholar
  52. Perry LP, Iwata M, Tazelaar HD et al (1998) Pulmonary mycotoxicosis: a clinicopathological study of three cases. Mod Pathol 11:432–436PubMedGoogle Scholar
  53. Pulimood TB, Corden JM, Bryden C et al (2007) Epidemic asthma and the role of the fungal mold Alternaria alternata. J Allergy Clin Immunol 120:610–617PubMedCrossRefGoogle Scholar
  54. Ratnaseelan AM, Tsilioni I, Theoharides TC (2018) Effects of mycotoxins on neuropsychiatric symptoms and immune processes. Clin Ther 40(6):903–917PubMedCrossRefGoogle Scholar
  55. Richard JL (2007) Some major mycotoxins and their mycotoxicoses-an overview. Int J Food Microbiol 119(1–2):3–10PubMedCrossRefGoogle Scholar
  56. Romero A d C, Ferreira TRB, Dias CT d S, Calori-Domingues MA, Glória EM d (2010) Occurrence of AFM1 in urine samples of a Brazilian population and association with food consumption [Internet]. Food Control 21(4):554–558CrossRefGoogle Scholar
  57. Ruzer LS, Harley NH (2005) Aerosols handbook: measurement, dosimetry and health effects. CRC Press, Boca RatonGoogle Scholar
  58. Saad S, Awad A-H, Aziz H (2006) Assessment of respiratory health problems due to exposure to airborne fungi in ceramics industry. Egypt J Occup Med 30(2):193–216Google Scholar
  59. Saad-Hussein A, El-Mofty HM, Hassanien MA (2011). Climate change and funfal keratitis trend: In Egypt. Eastern Med Health J 17(6):468–473Google Scholar
  60. Saad-Hussein A, Beshir S, Moubarz G et al (2013a) Effect of occupational exposure to aflatoxins on some liver tumor markers in textile workers. Am J Ind Med 56(7):818–824PubMedCrossRefGoogle Scholar
  61. Saad-Hussein A, El-Ghor AA, Noshy MM et al (2013b) Hepatotoxic effect of aflatoxin B1 and polymorphisms in glutathione S-transferase in millers occupationally exposed to Aspergillus. J Appl Sci Res 9(3):1724–1730Google Scholar
  62. Saad-Hussein A, Taha MM, Beshir S et al (2014a) Carcinogenic effects of aflatoxin B1 among wheat handlers. Int J Occup Environ Health 20(3):215–219PubMedPubMedCentralCrossRefGoogle Scholar
  63. Saad-Hussein A, Abdalla MS, Shousha WG et al (2014b) Oxidative role of aflatoxin B1 on the liver of wheat milling workers. Maced J Med Sci 7(1):141–146CrossRefGoogle Scholar
  64. Saad-Hussein A, Shahy EM, Shaheen W et al (2016a) Comparative hepatotoxicity of aflatoxin B1 among workers exposed to different organic dust with emphasis on polymorphism role of glutathione S-transferase gene. Maced J Med Sci 4(2):312–318CrossRefGoogle Scholar
  65. Saad-Hussein A, Taha MM, Fadl NN et al (2016b) Effects of airborne Aspergillus on serum aflatoxin B1 and liver enzymes in workers handling wheat flour. Hum Exp Toxicol 35(1):3–9PubMedCrossRefGoogle Scholar
  66. Schaafsma AW, Hooker DC (2007) Climatic models to predict occurrence of Fusarium toxins in wheat and maize. Int J Food Microbiol 119(1–2):116–125PubMedCrossRefGoogle Scholar
  67. Song E, Xia X, Su C et al (2014) Hepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administration. Food Chem Toxicol 71:122–127PubMedCrossRefGoogle Scholar
  68. Targonski PV, Persky VW, Ramekrishnan V (1995) Effect of environmental molds on risk of death from asthma during the pollen season. J Allergy Clin Immunol 95:955–961PubMedCrossRefGoogle Scholar
  69. Troutt C, Levetin E (2001) Correlation of spring spore concentrations and meteorological conditions in Tulsa, Oklahoma. Int J Biometeorol 45:64–74PubMedCrossRefGoogle Scholar
  70. Wang JS, Huang T, Su J et al (2001) Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People’s Republic of China. Cancer Epidemiol Biomark Prev 10:143–146Google Scholar
  71. Womack AM, Artaxo PE, Ishida FY et al (2015) Characterization of active and total fungal communities in the atmosphere over the Amazon rainforest. Biogeosciences 12:6337–6349CrossRefGoogle Scholar
  72. Yin YN, Yan LY, Jiang JH, Ma ZH (2008) Biological control of aflatoxin contamination of crops. J Zhejiang Univ Sci B 9(10):787–792PubMedPubMedCentralCrossRefGoogle Scholar
  73. Zhang X, Boesch-Saadatmandi C, Lou Y et al (2009) Ochratoxin A induces apoptosis in neuronal cells. Genes Nutr 4:41–48PubMedPubMedCentralCrossRefGoogle Scholar
  74. Zhu JQ, Zhang LS, Hu X et al (1987) Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer Res 47:1848–1852PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Environmental & Occupational MedicineNational Research Centre CairoEgypt

Section editors and affiliations

  • Yousef S. Khader
    • 1
  1. 1.Department of Community Medicine, Public Health and Family Medicine, Faculty of MedicineJordan University of Science & TechnologyIrbidJordan

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