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Skin: Cutibacterium (formerly Propionibacterium) acnes and Acne Vulgaris

  • Holger BrüggemannEmail author
Living reference work entry
Part of the Handbook of Hydrocarbon and Lipid Microbiology book series (HHLM)

Abstract

Acne vulgaris is an extremely common condition, experienced by approximately 80% of adolescents. The initiation of this disease and the chain of events in acne formation are poorly understood. The Gram-positive omnipresent skin commensal Cutibacterium (formerly Propionibacterium) acnes has been identified as a contributing factor in acne, but the importance and the precise role of this bacterium in disease formation are still not understood in full detail.

Since the decipherment of the first genome of C. acnes in 2004, many new discoveries have been made that shed light on the dual role of this bacterium, i.e., its host-beneficial and host-detrimental properties. This chapter summarizes recent findings in C. acnes microbiology and host-interacting properties and discusses these in the context of the pathophysiology of acne vulgaris. Based on these new discoveries, novel treatment strategies are being developed that aim to supersede the use of antibiotics.

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Authors and Affiliations

  1. 1.Department of BiomedicineAarhus UniversityAarhusDenmark

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