Autologous Mandril-Based Vascular Grafts

  • Wouter J. GeelhoedEmail author
  • Lorenzo Moroni
  • Joris I. Rotmans
Living reference work entry
Part of the Reference Series in Biomedical Engineering book series (RSBE)


It is well-known that the number of patients requiring a vascular graft for use as arterial bypass or as vascular access site for hemodialysis is ever increasing. The development of tissue-engineered vascular grafts (TEVGs) is a promising method to meet this increasing demand, without having to rely synthetic grafts such as polytetrafluoroethylene (PTFE) or Dacron, that have limited long-term durability. The generation of in vivo TEVGs involves utilizing the host reaction to an implanted biomaterial for the generation of completely autologous tissues. Essentially this approach to the development of TEVGs makes use of the foreign body response to biomaterials for the construction of the entire vascular replacement tissue within the patient’s own body. In this review we will discuss the method of developing in vivo TEVGs and debate the approaches of several research groups that have implemented this method.

This review is partly based on a previous publication in the Journal of Cardiovascular Translational Research (2017, 10(2):167–179) and includes an update with recent literature.


Conflicts of Interest

The authors have no conflicts of interest to disclose.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Wouter J. Geelhoed
    • 1
    • 2
    Email author
  • Lorenzo Moroni
    • 3
  • Joris I. Rotmans
    • 1
    • 2
  1. 1.Department of Internal MedicineLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Eindhoven Laboratory of Experimental Vascular MedicineLeiden University Medical CenterLeidenThe Netherlands
  3. 3.MERLN Institute for Technology Inspired Regenerative Medicine, Complex Tissue RegenerationMaastricht UniversityMaastrichtThe Netherlands

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