Encyclopedia of Gerontology and Population Aging

Living Edition
| Editors: Danan Gu, Matthew E. Dupre

DNA Chip

  • Parker Y. L. TsangEmail author
  • Sunny L. H. Chu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-69892-2_927-1
  • 8 Downloads

Synonyms

Definition

A DNA chip is used for performing sequence analysis or detection of nucleic acids on a tiny footprint of substrate. Labeled nucleic acid samples are hybridized only with the spots on substrate fixed with their complementary sequences. Through identifying the address of signaled spots, existence of particular sequences of interest can be determined and interrogated. It is a time- and cost-effective analysis option alternative to other detection technology. To some extent, the DNA chip can also refer to an integration of conventional laboratory functions into a handy chip. This technology has broadly been utilized in the fields such as genomic analysis and disease detections.

Overview

Advancement in DNA sequencing technology has allowed scientists to decode the sequences of nucleic acids in the human genomes. Approximately 30,000 genes have already been discovered in the human genome project (Deloukas et al. 1998). It has...

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Emerging Viral Diagnostics (HK) LimitedHong KongChina

Section editors and affiliations

  • Lok Ting Lau
    • 1
  1. 1.Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityKowloonHong Kong