Encyclopedia of Gerontology and Population Aging

Living Edition
| Editors: Danan Gu, Matthew E. Dupre

Alzheimer’s Disease

  • Yat-Fung Shea
  • Steven T. DeKoskyEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-69892-2_665-1
  • 12 Downloads

Synonyms

Definition

Alzheimer’s disease is a chronic neurodegenerative disease characterized neuropathologically by the presence of amyloid plaques and neurofibrillary tangles.

Overview

The clinical syndrome and pathological features of Alzheimer’s disease (AD) were first described by Alois Alzheimer, a psychiatrist and neuropathologist, when he worked at the state asylum in Frankfurt, Germany, at the turn of the twentieth century (Alzheimer et al. 1995). He described the symptoms in a 51-year-old woman, Auguste Deter (Maurer 1998), who was brought to his clinic. He subsequently identified neuritic plaques, neurofibrillary tangles (NFT), and amyloid angiopathy. Alzheimer’s mentor, the great psychiatrist Emil Kraepelin, credited him and coined the term “Alzheimer’s disease” in his own Handbook of Psychiatry (Maurer 1998). The young age of his patient led AD to be regarded as a rare neurodegenerative disease of mid-life, with only occasional cases...

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Medicine, Li Ka Shing Faculty of MedicineQueen Mary Hospital, University of Hong KongHong KongHong Kong
  2. 2.Department of Neurology and McKnight Brain InstituteUniversity of FloridaGainesvilleUSA

Section editors and affiliations

  • Adam J. Woods
    • 1
    • 2
  1. 1.Department of Clinical and Health Psychology, College of Public Health and Health Professions, Center for Cognitive Aging and MemoryMcKnight Brain Institute, University of FloridaGainesvilleUSA
  2. 2.Department of NeuroscienceUniversity of FloridaGainesvilleUSA