Encyclopedia of Gerontology and Population Aging

Living Edition
| Editors: Danan Gu, Matthew E. Dupre

Prevention of Age-Related Cognitive Impairment, Alzheimer’s Disease, and Dementia

  • Francesca MangialascheEmail author
  • Miia Kivipelto
  • Patrizia Mecocci
  • Tiia Ngandu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-69892-2_538-1


Prevention is traditionally divided into different levels, including primary prevention, which aims to reduce the incidence of the disease by eliminating or treating specific risk factors; secondary prevention, which focuses on the early detection of the disease, before any symptom has emerged, when treatment could stop its progression; and tertiary prevention, which seeks to reduce the impact of complications and disability of long-term diseases. This categorization is not very distinct in the dementia field, where some risk factors (e.g., hypertension) are equated to diseases, for purposes of intervention (Starfield et al. 2008). Additionally, many diseases causing dementia have a long preclinical phase, further blurring the boundaries between the different prevention levels. In Alzheimer’s disease (AD), the most common neurodegenerative disease underlying late-life cognitive impairment, cognitive problems are often preceded by a long period of about two or three decades,...

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Francesca Mangialasche
    • 1
    Email author
  • Miia Kivipelto
    • 2
    • 3
    • 4
    • 5
  • Patrizia Mecocci
    • 6
  • Tiia Ngandu
    • 7
  1. 1.Division of Clinical Geriatrics and Aging Research Center, Center for Alzheimer ResearchKarolinska InstitutetStockholmSweden
  2. 2.Division of Clinical Geriatrics, Center for Alzheimer ResearchKarolinska InstitutetStockholmSweden
  3. 3.Stockholms SjukhemResearch & Development UnitStockholmSweden
  4. 4.Institute of Public Health and Clinical NutritionUniversity of Eastern FinlandKuopioFinland
  5. 5.The Ageing Epidemiology Research Unit, School of Public HealthImperial College LondonLondonUK
  6. 6.Institute of Gerontology and Geriatrics, Department of MedicineUniversity of Perugia and Clinical Unit of Geriatrics, S. Maria della Misericordia HospitalPerugiaItaly
  7. 7.Public Health Promotion UnitFinnish Institute for Health and WelfareHelsinkiFinland

Section editors and affiliations

  • M. Cristina Polidori
    • 1
  1. 1.Ageing Clinical ResearchUniversity Hospital of CologneKölnGermany