Encyclopedia of Gerontology and Population Aging

Living Edition
| Editors: Danan Gu, Matthew E. Dupre

Nutrition and Frailty

  • Josje D. SchoufourEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-69892-2_362-1

Overview

Methods to Study the Association Between Nutrition and Frailty

Diet is one of the most important modifiable factors that can affect frailty and the aging process (Kiefte-de Jong et al. 2014; Schoufour et al. 2019b). It can be studied from different perspectives. Traditionally, most research on nutrition and frailty is concentrated on the effects of single nutrients (e.g., proteins, vitamin D), single foods (e.g., kiwis, wine), or food groups (e.g., vegetables, dairy). The advantage of this approach is that they lead to clear dietary advice, often supported by biological pathways. For example, the established association between low protein intake and frailty has led to increased awareness of protein supplementation in frail older populations. Nevertheless, this approach also has its limitations. People do not consume single nutrients but foods that are combined into meals and follow a pattern throughout the day. Nutrients and foods may interact together in influencing...

This is a preview of subscription content, log in to check access.

References

  1. Agarwal E, Miller M, Yaxley A, Isenring E (2013) Malnutrition in the elderly: a narrative review. Maturitas 76:296–302.  https://doi.org/10.1016/j.maturitas.2013.07.013CrossRefGoogle Scholar
  2. Artaza-Artabe I, Sáez-López P, Sánchez-Hernández N, Fernández-Gutierrez N, Malafarina V (2016) The relationship between nutrition and frailty: effects of protein intake, nutritional supplementation, vitamin D and exercise on muscle metabolism in the elderly. A systematic review. Maturitas 93:89–99.  https://doi.org/10.1016/j.maturitas.2016.04.009CrossRefGoogle Scholar
  3. Bartali B, Frongillo EA, Bandinelli S, Lauretani F, Semba RD, Fried LP, Ferrucci L (2006) Low nutrient intake is an essential component of frailty in older persons. J Gerontol A Biol Sci Med Sci 61:589–593.  https://doi.org/10.1093/gerona/61.6.589CrossRefGoogle Scholar
  4. Beasley JM, Shikany JM, Thomson CA (2013) The role of dietary protein intake in the prevention of sarcopenia of aging. Nutr Clin Pract 28:684–690.  https://doi.org/10.1177/0884533613507607CrossRefGoogle Scholar
  5. Blodgett J, Theou O, Kirkland S, Andreou P, Rockwood K (2015) The association between sedentary behaviour, moderate-vigorous physical activity and frailty in NHANES cohorts. Maturitas 80:187–191.  https://doi.org/10.1016/j.maturitas.2014.11.010CrossRefGoogle Scholar
  6. Bollwein J, Diekmann R, Kaiser MJ, Bauer JM, Uter W, Sieber CC, Volkert D (2013a) Dietary quality is related to frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 68:483–489.  https://doi.org/10.1093/gerona/gls204CrossRefGoogle Scholar
  7. Bollwein J, Volkert D, Diekmann R, Kaiser MJ, Uter W, Vidal K, Sieber CC, Bauer JM (2013b) Nutritional status according to the mini nutritional assessment (MNA®) and frailty in community dwelling older persons: a close relationship. J Nutr Health Aging 17:351–356.  https://doi.org/10.1007/s12603-013-0034-7CrossRefGoogle Scholar
  8. Bonnefoy M, Berrut G, Lesourd B, Ferry M, Gilbert T, Guérin O, Hanon O, Jeandel C, Paillaud E, Raynaud-Simon A, Ruault G, Rolland Y (2015) Frailty and nutrition: searching for evidence. J Nutr Health Aging 19:250–257.  https://doi.org/10.1007/s12603-014-0568-3CrossRefGoogle Scholar
  9. Brinkman S, Voortman T, Kiefte-de Jong JC, van Rooij FJA, Ikram MA, Rivadeneira F, Franco OH, Schoufour JD (2018) The association between lifestyle and overall health, using the frailty index. Arch Gerontol Geriatr 76:85–91.  https://doi.org/10.1016/j.archger.2018.02.006CrossRefGoogle Scholar
  10. Cermak NM, Res PT, de Groot LCPGM, Saris WHM, van Loon LJC (2012) Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr 96:1454–1464.  https://doi.org/10.3945/ajcn.112.037556CrossRefGoogle Scholar
  11. Cesari M, Landi F, Vellas B, Bernabei R, Marzetti E (2014) Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci 6:192.  https://doi.org/10.3389/fnagi.2014.00192CrossRefGoogle Scholar
  12. Cespedes EM, Hu FB (2015) Dietary patterns: from nutritional epidemiologic analysis to national guidelines. Am J Clin Nutr 101:899–900.  https://doi.org/10.3945/ajcn.115.110213CrossRefGoogle Scholar
  13. Cruz-Jentoft AJ, Kiesswetter E, Drey M, Sieber CC (2017) Nutrition, frailty, and sarcopenia. Aging Clin Exp Res 29:43–48.  https://doi.org/10.1007/s40520-016-0709-0CrossRefGoogle Scholar
  14. de Haas SCM, de Jonge EAL, Voortman T, Graaff JS, Franco OH, Ikram MA, Rivadeneira F, Kiefte-de Jong JC, Schoufour JD (2018) Dietary patterns and changes in frailty status: the Rotterdam Study. Eur J Nutr 57:2365–2375.  https://doi.org/10.1007/s00394-017-1509-9CrossRefGoogle Scholar
  15. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA, Cardiovascular Health Study Collaborative Research Group (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156.  https://doi.org/10.1093/gerona/56.3.m146CrossRefGoogle Scholar
  16. Haines PS, Siega-Riz AM, Popkin BM (1999) The Diet Quality Index revised: a measurement instrument for populations. J Am Diet Assoc 99:697–704.  https://doi.org/10.1016/S0002-8223(99)00168-6CrossRefGoogle Scholar
  17. Hu FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13:3–9.  https://doi.org/10.1097/00041433-200202000-00002CrossRefGoogle Scholar
  18. Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K (2010) Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci 65:377–381.  https://doi.org/10.1093/gerona/glp186CrossRefGoogle Scholar
  19. Kant AK (2004) Dietary patterns and health outcomes. J Am Diet Assoc 104:615–635.  https://doi.org/10.1016/j.jada.2004.01.010CrossRefGoogle Scholar
  20. Keevil VL, Romero-Ortuno R (2015) Ageing well: a review of sarcopenia and frailty. Proc Nutr Soc 74:337–347.  https://doi.org/10.1017/S0029665115002037CrossRefGoogle Scholar
  21. Kelaiditi E, Guyonnet S, Cesari M (2015) Is nutrition important to postpone frailty? Curr Opin Clin Nutr Metab Care 18:37–42.  https://doi.org/10.1097/MCO.0000000000000129CrossRefGoogle Scholar
  22. Kiefte-de Jong JC, Mathers JC, Franco OH (2014) Nutrition and healthy ageing: the key ingredients. Proc Nutr Soc 73(2):249–259.  https://doi.org/10.1017/S0029665113003881CrossRefGoogle Scholar
  23. Kim J-S, Wilson JM, Lee S-R (2010) Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants. J Nutr Biochem 21:1–13.  https://doi.org/10.1016/j.jnutbio.2009.06.014CrossRefGoogle Scholar
  24. Kruizenga HM, Wierdsma NJ, van Bokhorst MA, de van der Schueren HHJ, Jonkers-Schuitema CF, van der Heijden E, Melis GC, van Staveren WA (2003) Screening of nutritional status in The Netherlands. Clin Nutr 22:147–152.  https://doi.org/10.1054/clnu.2002.0611CrossRefGoogle Scholar
  25. Lana A, Rodriguez-Artalejo F, Lopez-Garcia E (2015) Dairy consumption and risk of frailty in older adults: a prospective cohort study. J Am Geriatr Soc 63:1852–1860.  https://doi.org/10.1111/jgs.13626CrossRefGoogle Scholar
  26. León-Muñoz LM, Guallar-Castillón P, López-García E, Rodríguez-Artalejo F (2014) Mediterranean diet and risk of frailty in community-dwelling older adults. J Am Med Dir Assoc 15:899–903.  https://doi.org/10.1016/j.jamda.2014.06.013CrossRefGoogle Scholar
  27. Lorenzo-López L, Maseda A, de Labra C, Regueiro-Folgueira L, Rodríguez-Villamil JL, Millán-Calenti JC (2017) Nutritional determinants of frailty in older adults: a systematic review. BMC Geriatr 17:108.  https://doi.org/10.1186/s12877-017-0496-2CrossRefGoogle Scholar
  28. Mitnitski AB, Mogilner AJ, Rockwood K (2001) Accumulation of deficits as a proxy measure of aging. Sci World J 1:323–336.  https://doi.org/10.1100/tsw.2001.58CrossRefGoogle Scholar
  29. Schoufour JD, Franco OH, Kiefte-de Jong JC, Trajanoska K, Stricker B, Brusselle G, Rivadeneira F, Lahousse L, Voortman T (2019a) The association between dietary protein intake, energy intake and physical frailty: results from the Rotterdam Study. Br J Nutr 121:393–401.  https://doi.org/10.1017/S0007114518003367CrossRefGoogle Scholar
  30. Schoufour JD, Overdevest E, Weijs PJM, Tieland M (2019b) Dietary protein, exercise, and frailty domains. Nutrients 11(10).  https://doi.org/10.3390/nu11102399CrossRefGoogle Scholar
  31. Shikany JM, Barrett-Connor E, Ensrud KE, Cawthon PM, Lewis CE, Dam T-TL, Shannon J, Redden DT, Osteoporotic Fractures in Men (MrOS) Research Group (2014) Macronutrients, diet quality, and frailty in older men. J Gerontol A Biol Sci Med Sci 69:695–701.  https://doi.org/10.1093/gerona/glt196CrossRefGoogle Scholar
  32. Smit E, Winters-Stone KM, Loprinzi PD, Tang AM, Crespo CJ (2013) Lower nutritional status and higher food insufficiency in frail older US adults. Br J Nutr 110:172–178.  https://doi.org/10.1017/S000711451200459XCrossRefGoogle Scholar
  33. Talegawkar SA, Bandinelli S, Bandeen-Roche K, Chen P, Milaneschi Y, Tanaka T, Semba RD, Guralnik JM, Ferrucci L (2012) A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women. J Nutr 142:2161–2166.  https://doi.org/10.3945/jn.112.165498CrossRefGoogle Scholar
  34. Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LCPGM, van Loon LJC (2012) Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 13:713–719.  https://doi.org/10.1016/j.jamda.2012.05.020CrossRefGoogle Scholar
  35. Tribess S, Virtuoso Júnior JS, Oliveira RJ (2012) Physical activity as a predictor of absence of frailty in the elderly. Rev Assoc Med Bras (1992) 58:341–347Google Scholar
  36. Verspoor E, Voortman T, van Rooij FJA, Rivadeneira F, Franco OH, Kiefte-de Jong JC, Schoufour JD (2019) Macronutrient intake and frailty: the Rotterdam Study. Eur J NutrGoogle Scholar
  37. Woo J, Chan R, Leung J, Wong M (2010) Relative contributions of geographic, socioeconomic, and lifestyle factors to quality of life, frailty, and mortality in elderly. PLoS One 5:e8775.  https://doi.org/10.1371/journal.pone.0008775CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Faculty of Sports and Nutrition and Faculty of Health, Center of Expertise Urban VitalityAmsterdam University of Applied SciencesAmsterdamThe Netherlands

Section editors and affiliations

  • Olga Theou
    • 1
  1. 1.Department of MedicineDalhousie UniversityHalifaxCanada