Sclerosing Pneumocytoma, Lung
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Sclerosing haemangioma (now defunct).
A benign neoplasm derived from peripheral lung epithelium showing histological heterogeneity; solid cellular, sclerotic, hemorrhagic, and papillary areas are variably represented. Typically there is a dual cell population, those lining the papillae and glandular spaces and those rounded cells of the solid intervening tissue.
Although the commonest of the truly benign pulmonary neoplasms, these are still rare lesions. Rarer still in Caucasian populations, this lesion is more prevalent in East Asia where it matches typical carcinoid in case numbers.
There is a wide age range for reported cases, from teenage years to the elderly, but most patients are in their 40s or 50s.
There is a marked female predominance to a ratio of nearly 5:1.
These are lesions which are now recognized as arising from the peripheral lung epithelial compartment so that they tend to be peripheral and parenchymal in...
References and Further Reading
- Chan, A. C., & Chan, J. K. (2000). Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): A new clue to its histogenesis. American Journal of Surgical Pathology, 24, 531–536.Google Scholar
- Devouassoux-Shisheboran, M., Hayashi, T., Linnoila, R. I., et al. (2000). A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. American Journal of Surgical Pathology, 24, 906–916.CrossRefGoogle Scholar
- Flieder, D. B. (2013). Benign epithelial neoplasms and tumour-like proliferations of the lung. In P. S. Hasleton & D. B. Flieder (Eds.), Spencer’s pathology of the lung. Cambridge: Cambridge University Press.Google Scholar
- Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.Google Scholar