Organic Solvents

  • Sibylle SchliemannEmail author
  • Anders Boman
  • J. E. Wahlberg
Reference work entry


Industrial solvents are volatile organic liquids commonly used to dissolve other organic materials such as oils, fats, resins, rubber, lacquers, waxes, perfumes, and plastic. They have a very wide variety of uses, including:
  • Analytical chemistry

  • Carriers and intermediates in organic synthesis

  • Dyeing of paper, plastics, fabrics

  • Dry cleaning

  • Floor laying

  • Fuels, gasoline (Contestable 2017)

  • Graphic industries, rotogravure printing

  • Maintenance and machinery repair, mechanics (Warshaw et al. 2017)

  • Media for extraction processes

  • Metal degreasing Painting

  • Paint manufacturing

  • Production of glass-fiber-reinforced polyester

  • Professional cleaning (Gerster et al. 2014)

  • Spotting agents

  • Shoe manufacturing (Febriana et al. 2014)

  • Surface coating


Acute irritant contact dermatitis Allergic contact dermatitis Contact urticaria Dermatoses Occupational exposure limit values (OELs) REACH Regulation Scleroderma Steven-Johnson syndrome Turpentine Whitening 


  1. Bauer M, Rabens SF (1974) Cutaneous manifestations of trichloroethylene toxicity. Arch Dermatol 110(6):886–890PubMedCrossRefPubMedCentralGoogle Scholar
  2. Bauer A, Schmitt J, Bennett C, Coenraads PJ, Elsner P, English J et al (2010) Interventions for preventing occupational irritant hand dermatitis. Cochrane Database Syst Rev (6):CD004414Google Scholar
  3. Boman A, Mellstrom G (1989) Percutaneous absorption of 3 organic solvents in the guinea pig. (III). Effect of barrier creams. Contact Dermatitis 21(3):134–140CrossRefGoogle Scholar
  4. Bottomley WW, Sheehan-Dare RA, Hughes P, Cunliffe WJ (1993) A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents. Br J Dermatol 128(2):203–206PubMedPubMedCentralCrossRefGoogle Scholar
  5. Bovenzi M, Barbone F, Betta A, Tommasini M, Versini W (1995) Scleroderma and occupational exposure. Scand J Work Environ Health 21(4):289–292PubMedPubMedCentralCrossRefGoogle Scholar
  6. Brooks S, Anderson L, Emmet E, Carson A, Tsay J, Elia V et al (1980) The effects of protective equipment on styrene exposure in workers in the reinforced plastics industry. Arch Environ Health 35:287–294PubMedCrossRefGoogle Scholar
  7. Cahill JL, Williams JD, Matheson MC, Palmer AM, Burgess JA, Dharmage SC et al (2016) Occupational skin disease in Victoria, Australia. Australas J Dermatol 57(2):108–114PubMedCrossRefPubMedCentralGoogle Scholar
  8. Chao KP, Wang VS, Lee PH (2004) Modeling organic solvents permeation through protective gloves. J Occup Environ Hyg 1(2):57–61PubMedCrossRefPubMedCentralGoogle Scholar
  9. Coenraads PJ, Diepgen TL (2003) Problems with trials and intervention studies on barrier creams and emollients at the workplace. Int Arch Occup Environ Health 76(5):362–366PubMedCrossRefGoogle Scholar
  10. Contestable JJ (2017) Jet fuel-associated occupational contact dermatitis. Mil Med 182(3):e1870–e1873PubMedCrossRefPubMedCentralGoogle Scholar
  11. Czirjak L, Pocs E, Szegedi G (1994) Localized scleroderma after exposure to organic solvents. Dermatology 189(4):399–401CrossRefGoogle Scholar
  12. Diepgen TL, Elsner P, Schliemann S, Fartasch M, Kollner A, Skudlik C et al (2009) Guideline on the management of hand eczema ICD-10 code: L20. L23. L24. L25. L30. J Dtsch Dermatol Ges 7(Suppl 3):S1–S16PubMedGoogle Scholar
  13. Elsner P (2018) Classification of consumer products under the EU CLP regulation: what to consider when caring for contact dermatitis patients. Contact Dermatitis 78(1):1–6PubMedCrossRefPubMedCentralGoogle Scholar
  14. Febriana SA, Soebono H, Coenraads PJ (2014) Occupational skin hazards and prevalence of occupational skin diseases in shoe manufacturing workers in Indonesia. Int Arch Occup Environ Health 87(2):185–194PubMedCrossRefPubMedCentralGoogle Scholar
  15. Fisher AA (1978) Immediate and delayed allergic contact reactions to polyethylene glycol. Contact Dermatitis 4(3):135–138PubMedCrossRefPubMedCentralGoogle Scholar
  16. Fregert S (1974) Allergic contact dermatitis from dioxane in a solvent for cleaning metal parts. Contact Dermatitis Newslett 15:438Google Scholar
  17. Frosch PJ, Kurte A (1994) Efficacy of skin barrier creams (IV). The repetitive irritation test (RIT) with a set of 4 standard irritants. Contact Dermatitis 31(3):161–168PubMedCrossRefPubMedCentralGoogle Scholar
  18. Garcia-Gavin J, Lissens R, Timmermans A, Goossens A (2011) Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen? Contact Dermatitis 65(2):101–106PubMedCrossRefPubMedCentralGoogle Scholar
  19. Garcia-Gavin J, Lissens R, Timmermans A, Goossens A (2011) Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen? Contact Dermatitis 65(2):101–6. Scholar
  20. Gerster FM, Vernez D, Wild PP, Hopf NB (2014) Hazardous substances in frequently used professional cleaning products. Int J Occup Environ Health 20(1):46–60PubMedPubMedCentralCrossRefGoogle Scholar
  21. Goldsmith LB, Friberg SE, Wahlberg JE (1988) The effect of solvent extraction on the lipids of the stratum corneum in relation to observed immediate whitening of the skin. Contact Dermatitis 19(5):348–350PubMedCrossRefPubMedCentralGoogle Scholar
  22. Gollhausen R, Kligman AM (1985) Human assay for identifying substances which induce non-allergic contact urticaria: the NICU-test. Contact Dermatitis 13(2):98–106PubMedCrossRefPubMedCentralGoogle Scholar
  23. Goodfield MJ, Saihan EM (1988) Contact urticaria to naphtha present in a solvent. Contact Dermatitis 18(3):187PubMedCrossRefPubMedCentralGoogle Scholar
  24. Green BG, Shaffer GS (1993) The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 53(3):323–334PubMedCrossRefPubMedCentralGoogle Scholar
  25. Halkier-Sorensen L (1996) Occupational skin diseases. Contact Dermatitis 35(1 Suppl):1–120PubMedGoogle Scholar
  26. Hellerstrom S, Thyresson N, Blohm SG, Widmark G (1955) On the nature of the eczematogenic component of oxidized delta 3-carene. J Invest Dermatol 24(3):217–224PubMedCrossRefPubMedCentralGoogle Scholar
  27. Hellerstrom S, Thyresson N, Widmark G (1957) Chemical aspects on turpentine exzema. Dermatologica 115(3):277–286PubMedCrossRefPubMedCentralGoogle Scholar
  28. Iyadomi M, Higaki Y, Ichiba M, Morimoto M, Tomokuni K (1998) Evaluation of organic solvent-induced inflammation modulated by neuropeptides in the abdominal skin of hairless rats. Ind Health 36(1):40–51PubMedCrossRefPubMedCentralGoogle Scholar
  29. Karlberg AT, Dooms-Goossens A (1997) Contact allergy to oxidized d-limonene among dermatitis patients. Contact Dermatitis 36(4):201–206CrossRefGoogle Scholar
  30. Karlberg AT, Boman A, Melin B (1991) Animal experiments on the allergenicity of d-limonene – the citrus solvent. Ann Occup Hyg 35(4):419–426PubMedPubMedCentralGoogle Scholar
  31. Karlberg AT, Magnusson K, Nilsson U (1992) Air oxidation of d-limonene (the citrus solvent) creates potent allergens. Contact Dermatitis 26(5):332–340PubMedCrossRefGoogle Scholar
  32. Karlberg AT, Shao LP, Nilsson U, Gafvert E, Nilsson JL (1994) Hydroperoxides in oxidized d-limonene identified as potent contact allergens. Arch Dermatol Res 286(2):97–103PubMedCrossRefPubMedCentralGoogle Scholar
  33. Kettaneh A, Al Moufti O, Tiev KP, Chayet C, Toledano C, Fabre B et al (2007) Occupational exposure to solvents and gender-related risk of systemic sclerosis: a metaanalysis of case-control studies. J Rheumatol 34(1):97–103Google Scholar
  34. Kim D, Andersen ME, Nylander-French LA (2006) Dermal absorption and penetration of jet fuel components in humans. Toxicol Lett 165(1):11–21PubMedCrossRefPubMedCentralGoogle Scholar
  35. Klauder JV, Brill FA Jr (1947) Correlation of boiling ranges of some petroleum solvents with irritant action on skin. Arch Derm Syphilol 56(2):197–215PubMedCrossRefPubMedCentralGoogle Scholar
  36. Korinth G, Geh S, Schaller KH, Drexler H (2003) In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents. Int Arch Occup Environ Health 76(5):382–386CrossRefGoogle Scholar
  37. Kronevi T, Wahlberg JE, Holmberg B (1981) Skin pathology following epicutaneous exposure to seven organic solvents. Int J Tissue React 3(1):21–30PubMedPubMedCentralGoogle Scholar
  38. Lachapelle J-M (1996) Efficacy of protective creams and/or gels. Curr Probl Dermatol 25:182–192PubMedCrossRefPubMedCentralGoogle Scholar
  39. Lauwerys RR, Kivits A, Lhoir M, Rigolet P, Houbeau D, Buchet JP et al (1980) Biological surveillance of workers exposed to dimethylformamide and the influence of skin protection on its percutaneous absorption. Int Arch Occup Environ Health 45(3):189–203PubMedCrossRefGoogle Scholar
  40. Lessmann H, Schnuch A, Geier J, Uter W (2005) Skin-sensitizing and irritant properties of propylene glycol. Contact Dermatitis 53(5):247–259PubMedCrossRefPubMedCentralGoogle Scholar
  41. Lim YL, Goon A (2007) Occupational skin diseases in Singapore 2003–2004: an epidemiologic update. Contact Dermatitis 56(3):157–159PubMedCrossRefPubMedCentralGoogle Scholar
  42. Loffler H, Kampf G, Lachenmeier D, Diepgen TL, John SM (2012) Allergic or irritant contact dermatitis after patch testing with alcohol – that is the point. Contact Dermatitis 67(6):386–387; author reply 8PubMedCrossRefPubMedCentralGoogle Scholar
  43. Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S et al (2014) Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature. Autoimmun Rev 13(2):151–156PubMedCrossRefPubMedCentralGoogle Scholar
  44. McDougal JN, Rogers JV (2004) Local and systemic toxicity of JP-8 from cutaneous exposures. Toxicol Lett 149(1–3):301–308PubMedCrossRefPubMedCentralGoogle Scholar
  45. McDougal JN, Pollard DL, Weisman W, Garrett CM, Miller TE (2000) Assessment of skin absorption and penetration of JP-8 jet fuel and its components. Toxicol Sci 55(2):247–255PubMedCrossRefPubMedCentralGoogle Scholar
  46. Mellström G, Wahlberg J, Maibach H (1994) Protective gloves for occupational use. CRC, Boca RatonGoogle Scholar
  47. Menne T, Johansen JD, Sommerlund M, Veien NK (2011) Hand eczema guidelines based on the Danish guidelines for the diagnosis and treatment of hand eczema. Contact Dermatitis 65(1):3–12PubMedCrossRefPubMedCentralGoogle Scholar
  48. Meyer JD, Chen Y, Holt DL, Beck MH, Cherry NM (2000) Occupational contact dermatitis in the UK: a surveillance report from EPIDERM and OPRA. Occup Med (Lond) 50(4):265–273CrossRefGoogle Scholar
  49. Nakayama H, Kobayashi M, Takahashi M, Ageishi Y, Takano T (1988) Generalized eruption with severe liver dysfunction associated with occupational exposure to trichloroethylene. Contact Dermatitis 19(1):48–51PubMedPubMedCentralCrossRefGoogle Scholar
  50. Noiles K, Kudla I, DeKoven J (2010) Propylene glycol dermatitis in the printing industry: the fundamental role of a workplace visit. Dermatitis 21(1):E1–E4PubMedCrossRefGoogle Scholar
  51. Ophaswongse S, Maibach HI (1994) Alcohol dermatitis: allergic contact dermatitis and contact urticaria syndrome. A review. Contact Dermatitis 30(1):1–6CrossRefGoogle Scholar
  52. Phoon WH, Chan MO, Rajan VS, Tan KJ, Thirumoorthy T, Goh CL (1984) Stevens-Johnson syndrome associated with occupational exposure to trichloroethylene. Contact Dermatitis 10(5):270–276CrossRefGoogle Scholar
  53. Rilliet A, Hunziker N, Brun R (1980) Alcohol contact urticaria syndrome (immediate-type hypersensitivity). Case report. Dermatologica 161(6):361–364PubMedCrossRefPubMedCentralGoogle Scholar
  54. Rudzki E, Berova N, Czernielewski A, Grzywa Z, Hegyi E, Jirasek J et al (1991) Contact allergy to oil of turpentine: a 10-year retrospective view. Contact Dermatitis Research Group in Comecon Countries. Contact Dermatitis 24(4):317–318PubMedCrossRefPubMedCentralGoogle Scholar
  55. Saito A, Tanaka H, Usuda H, Shibata T, Higashi S, Yamashita H et al (2009) Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice. Environ Toxicol 26(3):224–232CrossRefGoogle Scholar
  56. Schliemann S, Antonov D, Manegold N, Elsner P (2010) The lactic acid stinging test predicts susceptibility to cumulative irritation caused by two lipophilic irritants. Contact Dermatitis 63(6):347–356PubMedCrossRefPubMedCentralGoogle Scholar
  57. Schliemann S, Antonov D, Manegold N, Elsner P (2011) Sensory irritation caused by two organic solvents-short-time single application and repeated occlusive test in stingers and non-stingers. Contact Dermatitis 65:107PubMedCrossRefPubMedCentralGoogle Scholar
  58. Schliemann S, Kleesz P, Elsner P (2013) Protective creams fail to prevent solvent-induced cumulative skin irritation – results of a randomized double-blind study. Contact Dermatitis 69(6):363–371CrossRefGoogle Scholar
  59. Schliemann S, Schmidt C, Elsner P (2014) Tandem repeated application of organic solvents and sodium lauryl sulphate enhances cumulative skin irritation. Skin Pharmacol Physiol 27(3):158–63PubMedCrossRefPubMedCentralGoogle Scholar
  60. Schliemann-Willers S, Wigger-Alberti W, Elsner P (2001) Efficacy of a new class of perfluoropolyethers in the prevention of irritant contact dermatitis. Acta Derm Venereol 81(6):392–394CrossRefGoogle Scholar
  61. Sjoborg S, Fregert S, Trulsson L (1984) Contact allergy to styrene and related chemicals. Contact Dermatitis 10(2):94–96PubMedCrossRefPubMedCentralGoogle Scholar
  62. Stewart RD, Hake CL, Peterson JE (1974) Degreaser’s flush. Arch Environ Health 29(1):1–5PubMedCrossRefPubMedCentralGoogle Scholar
  63. Treudler R, Richter G, Geier J, Schnuch A, Orfanos CE, Tebbe B (2000) Increase in sensitization to oil of turpentine: recent data from a multicenter study on 45,005 patients from the German-Austrian Information Network of Departments of Dermatology (IVDK). Contact Dermatitis 42(2):68–73PubMedCrossRefPubMedCentralGoogle Scholar
  64. Vail JT, Letter J (1974) False-negative reaction to patch testing with volatile compounds. Arch Dermatol 110(1):130PubMedCrossRefPubMedCentralGoogle Scholar
  65. Varigos GA, Nurse DS (1986) Contact urticaria from methyl ethyl ketone. Contact Dermatitis 15(4):259–260PubMedCrossRefPubMedCentralGoogle Scholar
  66. Wahlberg J (1984a) Erythema-inducing effects of solvents following epicutaneous administration to man studied by laser Doppler flowmetry. Scand J Work Environ Health 10:159–162PubMedCrossRefPubMedCentralGoogle Scholar
  67. Wahlberg J (1984b) Edema-inducing effects of solvents following topical administration. Derm Beruf Umwelt 32:91–94PubMedPubMedCentralGoogle Scholar
  68. Wahlberg J (1989) Assessment of erythema: a comparison between the naked eye and laser Doppler flowmetry. In: Frosch P, Dooms-Goosens A, Lachapelle J, Rycroft R, Scheper R (eds) Current topics in contact dermatitis. Springer, Berlin/Heidelberg/New York, p 549CrossRefGoogle Scholar
  69. Wahlberg JE (1993) Measurement of skin-fold thickness in the guinea pig. Assessment of edema-inducing capacity of cutting fluids, acids, alkalis, formalin and dimethyl sulfoxide. Contact Dermatitis 28(3):141–145PubMedCrossRefPubMedCentralGoogle Scholar
  70. Wahlberg J (1994) Propylene glycol: search for a proper and nonirritant patch test preparation. Am J Contact Dermat 5:156–159CrossRefGoogle Scholar
  71. Wahlberg J (1995) Patch testing. In: Rycroft R, Menne T, Frosch P (eds) Textbook of contact dermatitis, 2nd edn. Springer, Berlin/Heidelberg/New York, p 243Google Scholar
  72. Wahlberg JE, Boman A (1996) Prevention of contact dermatitis from solvents. Curr Probl Dermatol 25:57–66PubMedCrossRefPubMedCentralGoogle Scholar
  73. Walder BK (1983) Do solvents cause scleroderma? Int J Dermatol 22(3):157–158PubMedPubMedCentralCrossRefGoogle Scholar
  74. Warshaw EM, Hagen SL, Sasseville D, Maibach HI, DeKoven JG, Belsito DV et al (2017) Occupational contact dermatitis in mechanics and repairers referred for patch testing: retrospective analysis from the North American Contact Dermatitis Group 1998–2014. Dermatitis 28(1):47–57PubMedCrossRefPubMedCentralGoogle Scholar
  75. Wigger-Alberti W, Rougier A, Richard A, Elsner P (1998) Efficacy of protective creams in a modified repeated irritation test. Methodological aspects. Acta Derm Venereol 78(4):270–273CrossRefGoogle Scholar
  76. Wigger-Alberti W, Krebs A, Elsner P (2000) Experimental irritant contact dermatitis due to cumulative epicutaneous exposure to sodium lauryl sulphate and toluene: single and concurrent application. Br J Dermatol 143(3):551–556CrossRefGoogle Scholar
  77. Wilkin JK, Fortner G (1985) Ethnic contact urticaria to alcohol. Contact Dermatitis 12(2):118–120PubMedCrossRefPubMedCentralGoogle Scholar
  78. Yamakage A, Ishikawa H (1982) Generalized morphea-like scleroderma occurring in people exposed to organic solvents. Dermatologica 165(3):186–193PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sibylle Schliemann
    • 1
    Email author
  • Anders Boman
    • 2
  • J. E. Wahlberg
    • 3
  1. 1.Department of DermatologyUniversity Hospital Jena, Friedrich-Schiller-UniversityJenaGermany
  2. 2.Department of Occupational and EnvironmentalKarolinska Institutet, Institute of Environmental Medicine, Occupational and Environmental DermatologyStockholmSweden
  3. 3.StockholmSweden

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