Immunology and Barrier Function of the Skin

  • Thomas RustemeyerEmail author
  • Manigé Fartasch
Reference work entry


A disturbed epidermal barrier may lead to irritant contact dermatitis.

An enhanced penetration through skin barrier may facilitate sensitization.

Immunological effects induced by pre-irritation and barrier alteration may further lead to the induction of allergic Type IV-contact dermatitis and Type I (immediate-type reaction) reactions or aggravate allergic reactions.


Atopic eczema (AE) Cornified cell envelope Epidermal permeability barrier Filaggrin Keratohyalin Netherton’s syndrome (NS) Transepidermal water loss (TEWL) 


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Authors and Affiliations

  1. 1.Department of Dermatology and AllergologyVU University Medical CenterAmsterdamThe Netherlands
  2. 2.Department for Clinical and Experimental Occupational DermatologyInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance/Institute of the Ruhr-UniversityBochumGermany

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