Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MRC2

  • Julian Hendrik Gronau
  • Clare M. Isacke
  • Justin Sturge
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_79

Synonyms

Historical Background

The MRC2 gene encodes the constitutively recycling type I transmembrane receptor Endo180 (Wu et al. 1996; Sheikh et al. 2000; Isacke et al. 1990), which is also cited in the literature as urokinase plasminogen activator receptor associated protein (uPARAP) following its identification as part of a trimolecular complex with pro-urokinase plasminogen activator (pro-uPA) and its receptor urokinase plasminogen activator receptor ( uPAR) (Behrendt et al. 2000). Endo180 is a member of the mannose receptor family, which also includes the mannose receptor (MR; CD206), M-type phospholipase A2 receptor, and DEC-205 (CD205) (East and Isacke 2002). The constitutive recycling of Endo180 between clathrin-coated pits at the plasma...

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References

  1. Behrendt N, Jensen ON, Engelholm LH, Mortz E, Mann M, Dano K. A urokinase receptor-associated protein with specific collagen binding properties. J Biol Chem. 2000;275:1993–2002.CrossRefPubMedGoogle Scholar
  2. Boskovic J, Arnold JN, Stilion R, Gordon S, Sim RB, Rivera-Calzada A, et al. Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J Biol Chem. 2006;281:8780–7.CrossRefPubMedGoogle Scholar
  3. East L, Isacke CM. The mannose receptor family. Biochim Biophys Acta. 2002;1572:364–86.CrossRefPubMedGoogle Scholar
  4. East L, Rushton S, Taylor ME, Isacke CM. Characterization of sugar binding by the mannose receptor family member, Endo180. J Biol Chem. 2002;277:50469–75.CrossRefPubMedGoogle Scholar
  5. East L, McCarthy A, Wienke D, Sturge J, Ashworth A, Isacke CM. A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep. 2003;4:710–6.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Engelholm LH, List K, Netzel-Arnett S, Cukierman E, Mitola DJ, Aaronson H, et al. uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol. 2003;160:1009–15.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Howard MJ, Isacke CM. The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. J Biol Chem. 2002;277:32320–31.CrossRefPubMedGoogle Scholar
  8. Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, et al. A role for fibrillar collagen deposition and the collagen internalization receptor Endo180 in glioma invasion. PLoS One. 2010;5:e9808.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Isacke CM, van der Geer P, Hunter T, Trowbridge IS. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol Cell Biol. 1990;10:2606–18.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Jansen KM, Pavlath GK. Mannose receptor regulates myoblast motility and muscle growth. J Cell Biol. 2006;174:403–13.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Kogianni G, Walker MM, Waxman J, Sturge J. Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. Eur J Cancer. 2009;45:685–93.CrossRefPubMedGoogle Scholar
  12. Rivera-Calzada A, Robertson D, MacFadyen JR, Boskovic J, Isacke CM, Llorca O. Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep. 2003;4:807–12.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Sheikh H, Yarwood H, Ashworth A, Isacke CM. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. J Cell Sci. 2000;113:1021–32.PubMedGoogle Scholar
  14. Sturge J, Wienke D, East L, Jones GE, Isacke CM. GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol. 2003;162:789–94.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Sturge J, Wienke D, Isacke CM. Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol. 2006;175:337–47.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, et al. Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells. J Neurooncol. 2010.  https://doi.org/10.1007/s11060-010-0398-z.
  17. Thomas EK, Nakamura M, Wienke D, Isacke CM, Pozzi A, Liang P. Endo180 binds to the C-terminal region of type I collagen. J Biol Chem. 2005;280:22596–605.CrossRefPubMedGoogle Scholar
  18. Wienke D, MacFadyen JR, Isacke CM. Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell. 2003;14:3592–604.PubMedPubMedCentralCrossRefGoogle Scholar
  19. Wienke D, Davies GC, Johnson DA, Sturge J, Lambros MB, Savage K, et al. The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Res. 2007;67:10230–40.CrossRefPubMedGoogle Scholar
  20. Wu K, Yuan J, Lasky LA. Characterization of a novel member of the macrophage mannose receptor type C lectin family. J Biol Chem. 1996;271:21323–30.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julian Hendrik Gronau
    • 1
  • Clare M. Isacke
    • 2
  • Justin Sturge
    • 1
  1. 1.Division of Cancer, Department of Surgery and CancerImperial College London, Hammersmith HospitalLondonUK
  2. 2.Breakthrough Breast Cancer Research CentreThe Institute of Cancer ResearchLondonUK