Steroid Receptor Coactivator Family
Steroid hormones have profound effects on physiology and behavior. Most of these biological effects of steroid hormones are mediated through their respective receptors, which are members of the steroid/nuclear receptor superfamily of transcriptional activators. These receptors can act in a classic genomic mechanism by interacting directly with DNA to alter transcription or at the membrane to rapidly activate cytoplasmic signaling pathways (Tetel and Lange 2009). In the classic genomic mechanism of action, nuclear receptor coregulators act to enhance (coactivators) or repress (corepressors) the transcriptional activity of these receptors. While over 300 coactivators have been identified to function in receptor transcription, the role of these coactivators in a wide range of human diseases is becoming better understood (Lonard et al. 2010). This review will focus...
Studies contributed by the author’s laboratory were supported by grants from National Science Foundation IBN 0080818 and National Institutes of Health R01 DK61935 (MJT).
- Agoulnik IU, Vaid A, Nakka M, Alvarado M, Bingman WE, Erdem H, Frolov A, Smith CL, Ayala GE, Ittmann MM, Weigel NL. Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res. 2006;66:10594–602.PubMedPubMedCentralCrossRefGoogle Scholar
- An BS, Selva DM, Hammond GL, Rivero-Muller A, Rahman N, Leung PC. Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells. J Biol Chem. 2006;281:20817–24.PubMedPubMedCentralCrossRefGoogle Scholar
- Jeong JW, Lee KY, Han SJ, Aronow BJ, Lydon JP, O’Malley BW, Demayo FJ. The p160 steroid receptor coactivator-2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression. Endocrinology. 2007;148:4238–50.PubMedPubMedCentralCrossRefGoogle Scholar