EphA3, Erythropoietin-Producing Hepatocellular Carcinoma Cell Receptor A3
A fragment of EphA3 was first cloned in 1991 by Sajjadi et al., in an expression-cloning screen of a chicken embryonic cDNA library using antibodies against phosphotyrosine (Sajjadi et al. 1991). Using this cDNA fragment as a probe, full-length cDNA from both chicken and mouse embryos were identified (Sajjadi et al. 1991). Human EphA3 was independently isolated as a cell surface antigen of a pre-B-cell leukemia cell line (Boyd et al. 1992; Wicks et al. 1992). EphA3 is a member of a large family of tyrosine kinase receptors, which plays many critical roles in both physiological and pathological conditions (Pasquale 2008).
The full-length human EphA3 protein consists of 983 amino acids, organized into the typical extracellular, transmembrane, and intracellular domains as that of other Eph family tyrosine kinase receptors (Wicks et al. 1992). A splice variant, which contains...
- Li YY, McTiernan CF, Feldman AM. IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes. Am J Phys. 1998;274:H331–41.Google Scholar
- Sieber BA, Kuzmin A, Canals JM, Danielsson A, Paratcha G, Arenas E, et al. Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Mol Cell Neurosci. 2004;26:418–28.CrossRefPubMedGoogle Scholar