Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Toll-Like Receptor 3

  • Aisha Qasim Butt
  • Sinéad M. MigginEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_607


Historical Background

The innate immune system of mammals is equipped with various kinds of cells, such as macrophages and dendritic cells (DCs), which provides the first line of defense to the host in recognizing various kinds of pathogens. These cells have developed different classes of protein based receptors for recognizing numerous kinds of pathogen associated molecular patterns (PAMPs) (Miggin and O’Neill 2006). These different classes of pathogen recognition receptors (PRRs) includes, Membrane bound PRRs such as Toll-like receptors (TLRs), Receptor kinases, Mannose receptors and Cytoplasmic PRRssuch as Nucleotide oligomerization domain (NOD) receptors, the Retinoic acid inducible gene I (RIG-I)-like receptor (RLR) family, and the recently described AIM2 and DAI cytosolic DNA receptors. All these receptor proteins play a crucial role in “danger” recognition and induction of the innate immune responses against a variety of bacterial and viral...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biology, Institute of ImmunologyNational University of Ireland MaynoothMaynoothIreland