Since 1996, when hematopoietic progenitor kinase 1 (HPK1) was first described as an activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathway (Kiefer et al. 1996), a range of information concerning activation, subcellular localization, putative interaction partners, and the regulatory function of HPK1 in immune cells was gathered. The initial studies showed that while HPK1 mRNA is ubiquitously detectable in embryonic tissues, expression in the adult is restricted to hematopoietic organs like thymus, bone marrow, and spleen. Protein database sequence comparison classified HPK1 as a member of the Ste20-related protein kinase family and is most closely related to the germinal center kinase (GCK), a MAP 4 kinase. The structure of HPK1 comprises an N-terminal kinase domain, a central region containing proline-rich...
- Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, et al. A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1. J Biol Chem. 1999;274(48):33945–50. [published erratum appears in J Biol Chem 2000 May 5;275(18):14004].CrossRefPubMedGoogle Scholar