Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Diego Martin-Sanchez
  • Miguel Fontecha-Barriuso
  • Maria D. Sanchez-Niño
  • Maria C. Izquierdo
  • Alvaro C. Ucero
  • Alberto Ortiz
  • Ana B. SanzEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_594



Fibroblast growth factor–inducible-14 (Fn14) was described in fibroblasts as an immediate-early response gene to growth factors. Fn14 is a member of the TNF receptor superfamily (TNFRSF), also termed TNFRSF12A. The only ligand for Fn14 is the cytokine TWEAK (Wiley and Winkles 2003), and Fn14 is the only signaling receptor for TWEAK. Both have been targeted therapeutically in humans.


Phylogenetically Fn14 is much conserved and there is a 90% homology between the mouse and the human protein (Wiley and Winkles 2003). The human Fn14 gene is located at chromosomal position 16p13.3, encodes a type I transmembrane protein of 129 aa that is processed into a mature 102-aa protein, and is the smallest member of the TNFRSF (Wiley and Winkles 2003). The extracellular domain (53-aa) contains a cysteine-rich domain typical of TNFRSF members, required for the interaction with TWEAK (He et al. 2009). Conversely, the Tyr176 residue of...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Diego Martin-Sanchez
    • 1
  • Miguel Fontecha-Barriuso
    • 1
  • Maria D. Sanchez-Niño
    • 1
  • Maria C. Izquierdo
    • 2
  • Alvaro C. Ucero
    • 3
  • Alberto Ortiz
    • 1
  • Ana B. Sanz
    • 1
    Email author
  1. 1.IIS-Fundacion Jimenez Diaz and Universidad Autonoma de MadridMadridSpain
  2. 2.Columbia University Medical CenterNew YorkUSA
  3. 3.Spanish National Cancer Research CenterMadridSpain