MyD88 (Myeloid Differentiation Primary Response Gene 88)
Myeloid differentiation primary response gene 88 (MyD88) was originally discovered and cloned by Liebermann and Hoffman in 1990 as one of the 12 different mRNA transcripts that were induced in M1 myeloblastic leukemia cells upon activation with lung-conditioned medium or recombinant interleukin (IL)-6 (Lord et al. 1990). The “MyD” portion of the name stands for myeloid differentiation, while “88” refers to the gene number in the list of induced genes (Lord et al. 1990). At the time of its discovery, the MyD88 sequence showed no homology with other sequences available in the databases and contained no recognizable protein motifs. In 1994, the C-terminal portion of MyD88 was found to be similar to a conserved stretch of approximately 200 amino acids in the intracellular regions of the Drosophila Toll receptor and the mammalian interleukin-1 receptor (IL-1R) (Hultmark 1994), and was thus...
This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059).
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